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PMID:22705394
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| Citation |
Burgo, A, Proux-Gillardeaux, V, Sotirakis, E, Bun, P, Casano, A, Verraes, A, Liem, RK, Formstecher, E, Coppey-Moisan, M and Galli, T (2012) A molecular network for the transport of the TI-VAMP/VAMP7 vesicles from cell center to periphery. Dev. Cell 23:166-80 |
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| Abstract |
The compartmental organization of eukaryotic cells is maintained dynamically by vesicular trafficking. SNARE proteins play a crucial role in intracellular membrane fusion and need to be targeted to their proper donor or acceptor membrane. The molecular mechanisms that allow for the secretory vesicles carrying the v-SNARE TI-VAMP/VAMP7 to leave the cell center, load onto microtubules, and reach the periphery to mediate exocytosis are largely unknown. Here, we show that the TI-VAMP/VAMP7 partner Varp, a Rab21 guanine nucleotide exchange factor, interacts with GolginA4 and the kinesin 1 Kif5A. Activated Rab21-GTP in turn binds to MACF1, an actin and microtubule regulator, which is itself a partner of GolginA4. These components are required for directed movement of TI-VAMP/VAMP7 vesicles from the cell center to the cell periphery. The molecular mechanisms uncovered here suggest an integrated view of the transport of vesicles carrying a specific v-SNARE toward the cell surface. |
| Links |
PubMed Online version:10.1016/j.devcel.2012.04.019 |
| Keywords |
Animals; COS Cells; Cercopithecus aethiops; Golgi Apparatus/metabolism; Growth Cones/drug effects; Growth Cones/metabolism; HeLa Cells; Humans; Kinesin/genetics; Kinesin/metabolism; Nocodazole/pharmacology; Protein Transport/drug effects; Protein Transport/physiology; R-SNARE Proteins/metabolism; RNA, Small Interfering/genetics; Tubulin Modulators/pharmacology |
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