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PMID:22712556
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| Citation |
Sreesankar, E, Senthilkumar, R, Bharathi, V, Mishra, RK and Mishra, K (2012) Functional diversification of yeast telomere associated protein, Rif1, in higher eukaryotes. BMC Genomics 13:255 |
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| Abstract |
Telomeres are nucleoprotein complexes at the end of linear eukaryotic chromosomes which maintain the genome integrity by regulating telomere length, preventing recombination and end to end fusion events. Multiple proteins associate with telomeres and function in concert to carry out these functions. Rap1 interacting factor 1 (Rif1), was identified as a protein involved in telomere length regulation in yeast. Rif1 is conserved upto mammals but its function has diversified from telomere length regulation to maintenance of genome integrity. |
| Links |
PubMed PMC3410773 Online version:10.1186/1471-2164-13-255 |
| Keywords |
Animals; Computational Biology; DNA Damage; Drosophila Proteins/antagonists & inhibitors; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/metabolism; Evolution, Molecular; HeLa Cells; Humans; Phylogeny; Protein Binding; Protein Phosphatase 1/chemistry; Protein Phosphatase 1/metabolism; RNA Interference; RNA, Small Interfering/metabolism; Repressor Proteins/classification; Repressor Proteins/genetics; Repressor Proteins/metabolism; Retroelements; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/classification; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; Telomere/metabolism; Telomere-Binding Proteins/classification; Telomere-Binding Proteins/genetics; Telomere-Binding Proteins/metabolism |
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