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HUMAN:PI3R6

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0042269

regulation of natural killer cell mediated cytotoxicity

PMID:11062502

ECO:0000314

P

Figs 1D and 1E show that inhibition of PI3K results in reduced NK cell cytoxicity

complete
CACAO 6114

protected

involved_in

GO:0042269

regulation of natural killer cell mediated cytotoxicity

PMID:11062502

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0046935

1-phosphatidylinositol-3-kinase regulator activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3U6Q4

F

Seeded From UniProt

complete

protected

contributes_to

GO:0046934

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3U6Q4

F

Seeded From UniProt

complete

protected

involved_in

GO:0045766

positive regulation of angiogenesis

PMID:21393242

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043406

positive regulation of MAP kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3U6Q4

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3U6Q4

C

Seeded From UniProt

complete

protected

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3U6Q4

P

Seeded From UniProt

complete

protected

part_of

GO:0005944

phosphatidylinositol 3-kinase complex, class IB

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3U6Q4

C

Seeded From UniProt

complete

protected

enables

GO:0046935

1-phosphatidylinositol-3-kinase regulator activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2144613
PANTHER:PTN001436768
RGD:1563261
UniProtKB:O02696

F

Seeded From UniProt

complete

protected

involved_in

GO:0043406

positive regulation of MAP kinase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2144613
PANTHER:PTN001436768
UniProtKB:O02696

P

Seeded From UniProt

complete

protected

involved_in

GO:0014065

phosphatidylinositol 3-kinase signaling

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001436768
UniProtKB:O02696

P

Seeded From UniProt

complete

protected

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2144613
PANTHER:PTN001436768
UniProtKB:O02696

P

Seeded From UniProt

complete

protected

part_of

GO:0005942

phosphatidylinositol 3-kinase complex

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001436768
RGD:1563261

C

Seeded From UniProt

complete

protected

involved_in

GO:0043551

regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046935

P

Seeded From UniProt

complete

protected

involved_in

GO:0043551

regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0046935

P

Seeded From UniProt

complete

protected

involved_in

GO:0043551

regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0046935

P

Seeded From UniProt

complete

protected

involved_in

GO:0043551

regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046935

P

Seeded From UniProt

complete

protected

involved_in

GO:0046854

phosphatidylinositol phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046934

P

Seeded From UniProt

complete

protected

involved_in

GO:0046854

phosphatidylinositol phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0046934

P

Seeded From UniProt

complete

protected

enables

GO:0046935

1-phosphatidylinositol-3-kinase regulator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U6Q4
ensembl:ENSMUSP00000052522

F

Seeded From UniProt

complete

protected

enables

GO:0046934

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U6Q4
ensembl:ENSMUSP00000052522

F

Seeded From UniProt

complete

protected

involved_in

GO:0045582

positive regulation of T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U6Q4
ensembl:ENSMUSP00000052522

P

Seeded From UniProt

complete

protected

involved_in

GO:0043406

positive regulation of MAP kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U6Q4
ensembl:ENSMUSP00000052522

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U6Q4
ensembl:ENSMUSP00000052522

C

Seeded From UniProt

complete

protected

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U6Q4
ensembl:ENSMUSP00000052522

P

Seeded From UniProt

complete

protected

part_of

GO:0005944

phosphatidylinositol 3-kinase complex, class IB

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3U6Q4
ensembl:ENSMUSP00000052522

C

Seeded From UniProt

complete

protected

part_of

GO:0005944

phosphatidylinositol 3-kinase complex, class IB

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019522

C

Seeded From UniProt

complete

protected

enables

GO:0046935

1-phosphatidylinositol-3-kinase regulator activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019522

F

Seeded From UniProt

complete

protected

involved_in

GO:0030168

platelet activation

Reactome:R-HSA-76002

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006661

phosphatidylinositol biosynthetic process

Reactome:R-HSA-1660499

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

Reactome:R-HSA-437162
Reactome:R-HSA-437118
Reactome:R-HSA-392300
Reactome:R-HSA-392295
Reactome:R-HSA-1676109
Reactome:R-HSA-1676048

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

protected

involved_in

GO:0001525

angiogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0037

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete




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