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HUMAN:MICA

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0032815

negative regulation of natural killer cell activation

PMID:20068167

ECO:0000314

P

Fig 6

complete
CACAO 6066

public

GO:0045953

negative regulation of natural killer cell mediated cytotoxicity

PMID:20068167

ECO:0000315

P

Fig 6 shows that the presence of MICA*008 compromises NK mediated lysis of cells.

complete
CACAO 6067

protected

involved_in

GO:0045953

negative regulation of natural killer cell mediated cytotoxicity

PMID:20068167

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032815

negative regulation of natural killer cell activation

PMID:20068167

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0009986

cell surface

PMID:18676862

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

PMID:18676862

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:18676862

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0051607

defense response to virus

PMID:16750166

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051607

defense response to virus

PMID:11224526

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0046703

natural killer cell lectin-like receptor binding

PMID:10426993

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P26718

F

Seeded From UniProt

complete

protected

enables

GO:0046703

natural killer cell lectin-like receptor binding

PMID:11491531

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0046629

gamma-delta T cell activation

PMID:9497295

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042742

defense response to bacterium

PMID:11830641

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042742

defense response to bacterium

PMID:11485740

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042267

natural killer cell mediated cytotoxicity

PMID:10426993

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

NOT|enables

GO:0030881

beta-2-microglobulin binding

PMID:8901601

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0009986

cell surface

PMID:8901601

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0009408

response to heat

PMID:8901601

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:15995699

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0002418

immune response to tumor cell

PMID:10359807

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0001913

T cell mediated cytotoxicity

PMID:10426993

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0046703

natural killer cell lectin-like receptor binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109431
MGI:MGI:109432
MGI:MGI:109477
MGI:MGI:1861032
MGI:MGI:1925027
MGI:MGI:2675273
MGI:MGI:3649078
MGI:MGI:3774845
PANTHER:PTN000422395
UniProtKB:Q29980
UniProtKB:Q29983
UniProtKB:Q6H3X3
UniProtKB:Q8TD07
UniProtKB:Q9BZM4
UniProtKB:Q9BZM5
UniProtKB:Q9BZM6

F

Seeded From UniProt

complete

protected

involved_in

GO:0042271

susceptibility to natural killer cell mediated cytotoxicity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109432
MGI:MGI:1925027
PANTHER:PTN000422395

P

Seeded From UniProt

complete

protected

involved_in

GO:0042267

natural killer cell mediated cytotoxicity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1861032
MGI:MGI:3649078
MGI:MGI:3774845
PANTHER:PTN000422395
UniProtKB:Q29983
UniProtKB:Q6H3X3
UniProtKB:Q8TD07
UniProtKB:Q9BZM4
UniProtKB:Q9BZM5
UniProtKB:Q9BZM6

P

Seeded From UniProt

complete

protected

involved_in

GO:0030101

natural killer cell activation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000422395
UniProtKB:Q9BZM4
UniProtKB:Q9BZM5
UniProtKB:Q9BZM6

P

Seeded From UniProt

complete

protected

part_of

GO:0009897

external side of plasma membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107674
MGI:MGI:109431
MGI:MGI:109432
MGI:MGI:1861032
MGI:MGI:1925027
MGI:MGI:2179988
MGI:MGI:2179989
MGI:MGI:95896
MGI:MGI:95904
MGI:MGI:95915
MGI:MGI:95938
PANTHER:PTN002314307
UniProtKB:Q30201

C

Seeded From UniProt

complete

protected

involved_in

GO:0006955

immune response

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002314307
UniProtKB:P01891
UniProtKB:Q31612

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95896
PANTHER:PTN002314307
UniProtKB:Q95460
UniProtKB:Q9BZM6

C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95929
PANTHER:PTN002314307
UniProtKB:P25311
UniProtKB:Q29983
UniProtKB:Q30201
UniProtKB:Q9BZM5

C

Seeded From UniProt

complete

protected

involved_in

GO:0001913

T cell mediated cytotoxicity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2675273
PANTHER:PTN000422395
UniProtKB:Q29983

P

Seeded From UniProt

complete

protected

involved_in

GO:0050776

regulation of immune response

Reactome:R-HSA-198933

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-198983

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

protected

involved_in

GO:0002250

adaptive immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1064

P

Seeded From UniProt

complete

protected

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

protected

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

involved_in

GO:0019835

cytolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0204

P

Seeded From UniProt

complete



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