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PMID:18624975
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| Citation |
Hsu, CC, Wu, WB and Huang, TF (2008) A snake venom metalloproteinase, kistomin, cleaves platelet glycoprotein VI and impairs platelet functions. J. Thromb. Haemost. 6:1578-85 |
|---|---|
| Abstract |
Injuries to the vessel wall and subsequent exposure of the matrix of the subendothelial layer resulted in thrombus formation. Platelet glycoprotein (GP) Ib and VI play a crucial role in matrix-induced activation and aggregation of platelets. |
| Links |
PubMed Online version:10.1111/j.1538-7836.2008.03071.x |
| Keywords |
Antigens, CD36/metabolism; Blood Platelets/cytology; Blood Platelets/drug effects; Blood Platelets/metabolism; Cell Adhesion; Collagen/metabolism; Crotalid Venoms/metabolism; Crotalid Venoms/pharmacology; Flow Cytometry; Humans; Hydrolysis; Metalloproteases/metabolism; Metalloproteases/pharmacology; Phosphorylation; Platelet Aggregation Inhibitors/metabolism; Platelet Aggregation Inhibitors/pharmacology; Recombinant Proteins/metabolism; Tyrosine/metabolism |
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