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PMID:21903815

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Citation

Yuan, Q, Xiang, Y, Yan, Z, Han, C, Jan, LY and Jan, YN (2011) Light-induced structural and functional plasticity in Drosophila larval visual system. Science 333:1458-62

Abstract

How to build and maintain a reliable yet flexible circuit is a fundamental question in neurobiology. The nervous system has the capacity for undergoing modifications to adapt to the changing environment while maintaining its stability through compensatory mechanisms, such as synaptic homeostasis. Here, we describe our findings in the Drosophila larval visual system, where the variation of sensory inputs induced substantial structural plasticity in dendritic arbors of the postsynaptic neuron and concomitant changes to its physiological output. Furthermore, our genetic analyses have identified the cyclic adenosine monophosphate (cAMP) pathway and a previously uncharacterized cell surface molecule as critical components in regulating experience-dependent modification of the postsynaptic dendrite morphology in Drosophila.

Links

PubMed Online version:10.1126/science.1207121

Keywords

Animals; Animals, Genetically Modified; Cyclic AMP/metabolism; Darkness; Dendrites/physiology; Dendrites/ultrastructure; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/genetics; Drosophila melanogaster/growth & development; Drosophila melanogaster/physiology; Larva/physiology; Light; Light Signal Transduction; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mutation; Neuronal Plasticity; Neurons/physiology; Neurons/ultrastructure; Photoreceptor Cells, Invertebrate/physiology; Photoreceptor Cells, Invertebrate/ultrastructure; Signal Transduction; Synapses/physiology; Visual Pathways

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