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PMID:22613836
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| Citation |
Gebert, M, Schrempp, SG, Mehnert, CS, Heißwolf, AK, Oeljeklaus, S, Ieva, R, Bohnert, M, von der Malsburg, K, Wiese, S, Kleinschroth, T, Hunte, C, Meyer, HE, Haferkamp, I, Guiard, B, Warscheid, B, Pfanner, N and van der Laan, M (2012) Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes. J. Cell Biol. 197:595-604 |
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| Abstract |
Many mitochondrial proteins are synthesized with N-terminal presequences in the cytosol. The presequence translocase of the inner mitochondrial membrane (TIM23) translocates preproteins into and across the membrane and associates with the matrix-localized import motor. The TIM23 complex consists of three core components and Tim21, which interacts with the translocase of the outer membrane (TOM) and the respiratory chain. We have identified a new subunit of the TIM23 complex, the inner membrane protein Mgr2. Mitochondria lacking Mgr2 were deficient in the Tim21-containing sorting form of the TIM23 complex. Mgr2 was required for binding of Tim21 to TIM23(CORE), revealing a binding chain of TIM23(CORE)-Mgr2/Tim21-respiratory chain. Mgr2-deficient yeast cells were defective in growth at elevated temperature, and the mitochondria were impaired in TOM-TIM23 coupling and the import of presequence-carrying preproteins. We conclude that Mgr2 is a coupling factor of the presequence translocase crucial for cell growth at elevated temperature and for efficient protein import. |
| Links |
PubMed PMC3365495 Online version:10.1083/jcb.201110047 |
| Keywords |
Cell Proliferation; Membrane Proteins/metabolism; Membrane Transport Proteins/chemistry; Membrane Transport Proteins/metabolism; Mitochondrial Membrane Transport Proteins/chemistry; Mitochondrial Membrane Transport Proteins/metabolism; Multiprotein Complexes/chemistry; Multiprotein Complexes/metabolism; Protein Subunits/metabolism; Protein Transport; Saccharomyces cerevisiae/cytology; Saccharomyces cerevisiae/growth & development; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/chemistry; Saccharomyces cerevisiae Proteins/metabolism; Temperature |
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