GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
TableEdit
PMID:20729808
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
See Help for Help on this wiki. See the documentation for how to use the table editor
| Citation |
Bernard, D, Prasanth, KV, Tripathi, V, Colasse, S, Nakamura, T, Xuan, Z, Zhang, MQ, Sedel, F, Jourdren, L, Coulpier, F, Triller, A, Spector, DL and Bessis, A (2010) A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression. EMBO J. 29:3082-93 |
|---|---|
| Abstract |
A growing number of long nuclear-retained non-coding RNAs (ncRNAs) have recently been described. However, few functions have been elucidated for these ncRNAs. Here, we have characterized the function of one such ncRNA, identified as metastasis-associated lung adenocarcinoma transcript 1 (Malat1). Malat1 RNA is expressed in numerous tissues and is highly abundant in neurons. It is enriched in nuclear speckles only when RNA polymerase II-dependent transcription is active. Knock-down studies revealed that Malat1 modulates the recruitment of SR family pre-mRNA-splicing factors to the transcription site of a transgene array. DNA microarray analysis in Malat1-depleted neuroblastoma cells indicates that Malat1 controls the expression of genes involved not only in nuclear processes, but also in synapse function. In cultured hippocampal neurons, knock-down of Malat1 decreases synaptic density, whereas its over-expression results in a cell-autonomous increase in synaptic density. Our results suggest that Malat1 regulates synapse formation by modulating the expression of genes involved in synapse formation and/or maintenance. |
| Links |
PubMed PMC2944070 Online version:10.1038/emboj.2010.199 |
| Keywords |
Animals; Biological Markers/metabolism; Blotting, Northern; Bone Neoplasms/genetics; Bone Neoplasms/metabolism; Bone Neoplasms/pathology; Cell Nucleus/genetics; Cell Nucleus/metabolism; Cells, Cultured; Gene Expression Profiling; Gene Expression Regulation/physiology; Hippocampus/cytology; Hippocampus/metabolism; Humans; Mice; Neuroblastoma/genetics; Neuroblastoma/metabolism; Neuroblastoma/pathology; Neurogenesis/physiology; Neurons/cytology; Neurons/metabolism; Oligonucleotide Array Sequence Analysis; Osteosarcoma/genetics; Osteosarcoma/metabolism; Osteosarcoma/pathology; RNA Precursors/genetics; RNA Splicing/genetics; RNA, Messenger/genetics; RNA, Nuclear/physiology; Reverse Transcriptase Polymerase Chain Reaction; Synapses/genetics; Transcription Factors/genetics; Transcription Factors/metabolism |
| public |
| Cancel |
