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PMID:16763112
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| Citation |
Yoshida, S, Kono, K, Lowery, DM, Bartolini, S, Yaffe, MB, Ohya, Y and Pellman, D (2006) Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science 313:108-11 |
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| Abstract |
The links between the cell cycle machinery and the cytoskeletal proteins controlling cytokinesis are poorly understood. The small guanine nucleotide triphosphate (GTP)-binding protein RhoA stimulates type II myosin contractility and formin-dependent assembly of the cytokinetic actin contractile ring. We found that budding yeast Polo-like kinase Cdc5 controls the targeting and activation of Rho1 (RhoA) at the division site via Rho1 guanine nucleotide exchange factors. This role of Cdc5 (Polo-like kinase) in regulating Rho1 is likely to be relevant to cytokinesis and asymmetric cell division in other organisms. |
| Links |
PubMed Online version:10.1126/science.1126747 |
| Keywords |
Actins/metabolism; Amino Acid Motifs; Anaphase; Cell Cycle Proteins/chemistry; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Cytokinesis; Guanine Nucleotide Exchange Factors/chemistry; Guanine Nucleotide Exchange Factors/genetics; Guanine Nucleotide Exchange Factors/metabolism; Guanosine Triphosphate/metabolism; Microfilament Proteins/metabolism; Mitosis; Mutation; Phosphorylation; Protein Kinases/chemistry; Protein Kinases/genetics; Protein Kinases/metabolism; Recombinant Fusion Proteins/metabolism; Saccharomyces cerevisiae/cytology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/chemistry; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; Temperature; rho GTP-Binding Proteins/metabolism |
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