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PMID:19606897

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Citation

Jian, X, Wasinger, EC, Lockard, JV, Chen, LX and He, C (2009) Highly sensitive and selective gold(I) recognition by a metalloregulator in Ralstonia metallidurans. J. Am. Chem. Soc. 131:10869-71

Abstract

A MerR family metalloregulatory protein CupR selectively responds to gold stress in Ralstonia metallidurans. A distorted trigonal geometry appears to be used by CupR to achieve the highly sensitive (K(d) approximately 10(-35) M) and selective recognition of gold(I).

Links

PubMed Online version:10.1021/ja904279n

Keywords

Bacterial Proteins/metabolism; Gold/pharmacokinetics; Protein Binding; Ralstonia/metabolism

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