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PMID:18391107
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| Citation |
Seddon, MD, Chowienczyk, PJ, Brett, SE, Casadei, B and Shah, AM (2008) Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo. Circulation 117:1991-6 |
|---|---|
| Abstract |
Nitric oxide (NO) has a pivotal role in the regulation of vascular tone and blood flow, with dysfunctional release contributing to disease pathophysiology. These effects have been attributed to NO production by the endothelial NO synthase (eNOS); however, recent evidence suggests that a neuronal NO synthase (nNOS) may also be expressed in arterial vessels. |
| Links |
PubMed Online version:10.1161/CIRCULATIONAHA.107.744540 |
| Keywords |
Acetylcholine/pharmacology; Acetylcholine/physiology; Adult; Arginine/pharmacology; Brachial Artery/drug effects; Brachial Artery/enzymology; Brachial Artery/physiology; Citrulline/analogs & derivatives; Citrulline/pharmacology; Forearm/blood supply; Humans; Male; Nitric Oxide/physiology; Nitric Oxide Synthase Type I/antagonists & inhibitors; Nitric Oxide Synthase Type I/physiology; Nitric Oxide Synthase Type III/physiology; Stress, Psychological/physiopathology; Thiourea/analogs & derivatives; Thiourea/pharmacology; Vasodilation; Vasomotor System/drug effects; Vasomotor System/physiology; omega-N-Methylarginine/pharmacology |
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