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MOUSE:RO52

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0032088

negative regulation of NF-kappaB transcription factor activity

PMID:19494276

ECO:0000269

P

Fig 8A: Analyses using a NF-κB-driven luciferase reporter for cells stimulated with LPS or poly(I:C). LPS- and poly(I:C)-induced luciferase activity was significantly higher in Trim21−/− cells than in Trim21+/+ cells

complete

public

GO:0032088

negative regulation of NF-kappaB transcription factor activity

PMID:19494276

ECO:0000269

P

Anaylses using a NF-kB driven luciferase reporter for cells stimulated with LPS or Poly (I:C) . As shown in Fig 8A, the LPS and Poly (I:C) - induced luciferase activity was significantly higher in Trim -/- than in Trim +/-

complete

protected

involved_in

GO:0034341

response to interferon-gamma

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

involved_in

GO:0010508

positive regulation of autophagy

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

involved_in

GO:0090086

negative regulation of protein deubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

involved_in

GO:0051865

protein autoubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

involved_in

GO:0045787

positive regulation of cell cycle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

involved_in

GO:0031648

protein destabilization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

colocalizes_with

GO:0019005

SCF ubiquitin ligase complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

C

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

involved_in

GO:0006513

protein monoubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P51965

C

Seeded From UniProt

complete

protected

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

F

Seeded From UniProt

complete

protected

involved_in

GO:0000209

protein polyubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1902187

negative regulation of viral release from host cell

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0090086

negative regulation of protein deubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0070206

protein trimerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051865

protein autoubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045787

positive regulation of cell cycle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045087

innate immune response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0034341

response to interferon-gamma

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032897

negative regulation of viral transcription

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0031648

protein destabilization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

colocalizes_with

GO:0019005

SCF ubiquitin ligase complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0016567

protein ubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0010508

positive regulation of autophagy

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006513

protein monoubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:11331580

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

C

Seeded From UniProt

complete

protected

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0000209

protein polyubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P19474

P

Seeded From UniProt

complete

protected

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000315
InterPro:IPR020457

F

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018957

F

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

protected

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

protected

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

part_of

GO:0000932

P-body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0230

C

Seeded From UniProt

complete

protected

part_of

GO:0005776

autophagosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0023

C

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete




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