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PMID:18535244
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| Citation |
Miyoshi, T, Kanoh, J, Saito, M and Ishikawa, F (2008) Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length. Science 320:1341-4 |
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| Abstract |
Telomeres are specialized chromatin structures that protect chromosomal ends. Protection of telomeres 1 (Pot1) binds to the telomeric G-rich overhang, thereby protecting telomeres and regulating telomerase. Mammalian POT1 and TPP1 interact and constitute part of the six-protein shelterin complex. Here we report that Tpz1, the TPP1 homolog in fission yeast, forms a complex with Pot1. Tpz1 binds to Ccq1 and the previously undiscovered protein Poz1 (Pot1-associated in Schizosaccharomyces pombe), which protect telomeres redundantly and regulate telomerase in positive and negative manners, respectively. Thus, the Pot1-Tpz1 complex accomplishes its functions by recruiting effector molecules Ccq1 and Poz1. Moreover, Poz1 bridges Pot1-Tpz1 and Taz1-Rap1, thereby connecting the single-stranded and double-stranded telomeric DNA regions. Such molecular architectures are similar to those of mammalian shelterin, indicating that the overall DNA-protein architecture is conserved across evolution. |
| Links |
PubMed Online version:10.1126/science.1154819 |
| Keywords |
Amino Acid Sequence; Carrier Proteins/chemistry; Carrier Proteins/genetics; Carrier Proteins/metabolism; Chromatin Immunoprecipitation; DNA, Fungal/metabolism; Immunoprecipitation; Molecular Sequence Data; Mutation; Protein Binding; Protein Structure, Tertiary; Schizosaccharomyces/genetics; Schizosaccharomyces/metabolism; Schizosaccharomyces pombe Proteins/chemistry; Schizosaccharomyces pombe Proteins/genetics; Schizosaccharomyces pombe Proteins/metabolism; Telomerase/metabolism; Telomere/metabolism; Telomere/physiology; Telomere/ultrastructure; Telomere-Binding Proteins/chemistry; Telomere-Binding Proteins/genetics; Telomere-Binding Proteins/metabolism; Two-Hybrid System Techniques |
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