GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
TableEdit
PMID:22449099
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
See Help for Help on this wiki. See the documentation for how to use the table editor
Citation |
Lee, M, Park, JJ, Ko, YG and Lee, YS (2012) Cleavage of ST6Gal I by radiation-induced BACE1 inhibits golgi-anchored ST6Gal I-mediated sialylation of integrin β1 and migration in colon cancer cells. Radiat Oncol 7:47 |
---|---|
Abstract |
Previously, we found that β-galactoside α2,6-sialyltransferase (ST6Gal I), an enzyme that adds sialic acids to N-linked oligosaccharides of glycoproteins and is frequently overexpressed in cancer cells, is up-regulated by ionizing radiation (IR) and cleaved to a form possessing catalytic activity comparable to that of the Golgi-localized enzyme. Moreover, this soluble form is secreted into the culture media. Induction of ST6Gal I significantly increased the migration of colon cancer cells via sialylation of integrin β1. Here, we further investigated the mechanisms underlying ST6Gal I cleavage, solubilization and release from cells, and addressed its functions, focusing primarily on cancer cell migration. |
Links |
PubMed PMC3351029 Online version:10.1186/1748-717X-7-47 |
Keywords |
Amyloid Precursor Protein Secretases/metabolism; Antigens, CD29/metabolism; Aspartic Acid Endopeptidases/metabolism; Cell Line, Tumor; Cell Movement/radiation effects; Colonic Neoplasms/metabolism; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Golgi Apparatus/metabolism; Humans; Immunoblotting; Immunoprecipitation; N-Acetylneuraminic Acid/metabolism; Radiation, Ionizing; Sialyltransferases/metabolism |
public |
Cancel |