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PMID:20812917
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Citation |
Watanabe, Y, Takeuchi, K, Higa Onaga, S, Sato, M, Tsujita, M, Abe, M, Natsume, R, Li, M, Furuichi, T, Saeki, M, Izumikawa, T, Hasegawa, A, Yokoyama, M, Ikegawa, S, Sakimura, K, Amizuka, N, Kitagawa, H and Igarashi, M (2010) Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. Biochem. J. 432:47-55 |
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Abstract |
CS (chondroitin sulfate) is a glycosaminoglycan species that is widely distributed in the extracellular matrix. To understand the physiological roles of enzymes involved in CS synthesis, we produced CSGalNAcT1 (CS N-acetylgalactosaminyltransferase 1)-null mice. CS production was reduced by approximately half in CSGalNAcT1-null mice, and the amount of short-chain CS was also reduced. Moreover, the cartilage of the null mice was significantly smaller than that of wild-type mice. Additionally, type-II collagen fibres in developing cartilage were abnormally aggregated and disarranged in the homozygous mutant mice. These results suggest that CSGalNAcT1 is required for normal CS production in developing cartilage. |
Links |
PubMed PMC2995422 Online version:10.1042/BJ20100847 |
Keywords |
Animals; Blotting, Western; Cell Line; Cell Proliferation; Chondrocytes/cytology; Chondrocytes/enzymology; Chondrocytes/metabolism; Chondrogenesis; Chondroitin Sulfates/biosynthesis; Collagen Type II/metabolism; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Growth Plate/embryology; Growth Plate/enzymology; Growth Plate/metabolism; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Acetylgalactosaminyltransferases/genetics; N-Acetylgalactosaminyltransferases/metabolism; Proliferating Cell Nuclear Antigen/metabolism; Reverse Transcriptase Polymerase Chain Reaction |
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