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PMID:22363646

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Citation

Zhu, H, Xia, L, Zhang, Y, Wang, H, Xu, W, Hu, H, Wang, J, Xin, J, Gang, Y, Sha, S, Xu, B, Fan, D, Nie, Y and Wu, K (2012) Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression. PLoS ONE 7:e31431

Abstract

Multidrug resistance (MDR) in gastric cancer remains a major challenge to clinical treatment. Activating transcription factor 4 (ATF4) is a stress response gene involved in homeostasis and cellular protection. However, the expression and function of ATF4 in gastric cancer MDR remains unknown. In this study, we investigate whether ATF4 play a role in gastric cancer MDR and its potential mechanisms.

Links

PubMed PMC3281959 Online version:10.1371/journal.pone.0031431

Keywords

Activating Transcription Factor 4/metabolism; Apoptosis/genetics; Base Sequence; Cell Line, Tumor; DNA Damage; Down-Regulation/genetics; Drug Resistance, Multiple/genetics; Drug Resistance, Neoplasm/genetics; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; P-Glycoprotein/genetics; P-Glycoprotein/metabolism; Phenotype; Promoter Regions, Genetic/genetics; RNA, Small Interfering/metabolism; Sirtuin 1/antagonists & inhibitors; Sirtuin 1/genetics; Sirtuin 1/metabolism; Stomach Neoplasms/genetics; Stomach Neoplasms/pathology; Transcriptional Activation/genetics; Transfection; Up-Regulation/genetics; bcl-2-Associated X Protein/genetics; bcl-2-Associated X Protein/metabolism

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