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PMID:10383417
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| Citation |
Tanaka, N, Kaneko, K, Asao, H, Kasai, H, Endo, Y, Fujita, T, Takeshita, T and Sugamura, K (1999) Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines. J. Biol. Chem. 274:19129-35 |
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| Abstract |
STAM containing an SH3 (Src homology 3) domain and an immunoreceptor tyrosine-based activation motif was previously revealed to be implicated in signaling pathways immediately downstream of Jak2 and Jak3 tyrosine kinases associated with cytokine receptors. We molecularly cloned a novel molecule interacting with the SH3 domain of STAM, which was named AMSH (associated molecule with the SH3 domain of STAM). AMSH contains a putative bipartite nuclear localization signal and a homologous region of a c-Jun activation domain-binding protein 1 (JAB1) subdomain in addition to a binding site for the SH3 domain of STAM. AMSH mutant deleted of the C-terminal half conferred dominant negative effects on signaling for DNA synthesis and c-myc induction mediated by interleukin 2 and granulocyte macrophage-colony-stimulating factor. These results suggest that AMSH plays a critical role in the cytokine-mediated intracellular signal transduction downstream of the Jak2/Jak3.STAM complex. |
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| Keywords |
Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cloning, Molecular; Consensus Sequence; DNA Replication; DNA-Binding Proteins/metabolism; Endosomal Sorting Complexes Required for Transport; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism; In Situ Hybridization, Fluorescence; Interleukin-2/metabolism; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Peptide Hydrolases; Phosphoproteins/metabolism; Proto-Oncogene Proteins c-myc/metabolism; Signal Transduction; Transcription Factors/metabolism; src Homology Domains |
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