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HUMAN:SODM

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0010212

response to ionizing radiation

PMID:22302046

ECO:0000315

P

Reactive oxygen species harm the cell. SOD2 moderates this destruction. See Figure 3 & Table 1.

complete
CACAO 3844

public

GO:0050369

[tyrosine 3-monooxygenase] kinase activity

PMID:9425011

ECO:0000314

F

Fig. 1.Expression of human MnSOD in PC6 cells: localization to the mitochondria and protection against oxidative stress-induced apoptosis.

complete
CACAO 5940

protected

involved_in

GO:1905932

positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching

PMID:27021683

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0002591)

Seeded From UniProt

complete

protected

involved_in

GO:1905461

positive regulation of vascular associated smooth muscle cell apoptotic process

PMID:27021683

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0002591)

Seeded From UniProt

complete

protected

involved_in

GO:1904706

negative regulation of vascular smooth muscle cell proliferation

PMID:27021683

ECO:0000314

direct assay evidence used in manual assertion

P

results_in_division_of:(CL:0002591)

Seeded From UniProt

complete

protected

part_of

GO:0005759

mitochondrial matrix

PMID:23168492

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0030335

positive regulation of cell migration

PMID:20489163

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_o_results_in_movement_of:(CL:0002619)

Seeded From UniProt

complete

protected

part_of

GO:0070062

extracellular exosome

PMID:23533145

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:1902176

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

PMID:12551919

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043524

negative regulation of neuron apoptotic process

PMID:17251466

ECO:0000316

genetic interaction evidence used in manual assertion

P

Seeded From UniProt

Missing: with/from

protected

involved_in

GO:0032364

oxygen homeostasis

PMID:16179351

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0019430

removal of superoxide radicals

PMID:16179351

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:16179351

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008217

regulation of blood pressure

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09671

P

Seeded From UniProt

complete

protected

involved_in

GO:0006801

superoxide metabolic process

PMID:12551919

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

PMID:12551919

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0004784

superoxide dismutase activity

PMID:12551919

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0003069

acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09671

P

Seeded From UniProt

complete

protected

involved_in

GO:0001836

release of cytochrome c from mitochondria

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P09671

P

Seeded From UniProt

complete

protected

involved_in

GO:0000303

response to superoxide

PMID:16179351

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051289

protein homotetramerization

PMID:19265433

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P04179

P

Seeded From UniProt

complete

protected

enables

GO:0030145

manganese ion binding

PMID:19265433

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0006801

superoxide metabolic process

PMID:14980699

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:9393747

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0004784

superoxide dismutase activity

PMID:19265433

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004784

superoxide dismutase activity

PMID:14980699

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0001315

age-dependent response to reactive oxygen species

PMID:14980699

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000150074
UniProtKB:O81235

F

Seeded From UniProt

complete

protected

enables

GO:0030145

manganese ion binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000150074
PomBase:SPAC1486.01
RGD:3732
UniProtKB:P04179
UniProtKB:Q92450

F

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98352
PANTHER:PTN000150076
PomBase:SPAC1486.01
RGD:3732
SGD:S000001050
UniProtKB:O81235
UniProtKB:P04179
UniProtKB:P09233
WB:WBGene00004932

C

Seeded From UniProt

complete

protected

enables

GO:0004784

superoxide dismutase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98352
PANTHER:PTN000150074
PomBase:SPAC1486.01
RGD:3732
SGD:S000001050
UniProtKB:A0A1D8PQH5
UniProtKB:O81235
UniProtKB:P04179
UniProtKB:P09233
UniProtKB:P9WGE7
WB:WBGene00004931
WB:WBGene00004932

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:21988832

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P04179

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:19822147

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P04179

F

Seeded From UniProt

complete

protected

enables

GO:0004784

superoxide dismutase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001189
InterPro:IPR019831
InterPro:IPR019832
InterPro:IPR019833

F

Seeded From UniProt

complete

protected

involved_in

GO:0006801

superoxide metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001189
InterPro:IPR019831
InterPro:IPR019832
InterPro:IPR019833

P

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001189
InterPro:IPR019831
InterPro:IPR019832
InterPro:IPR019833

F

Seeded From UniProt

complete

protected

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001189
InterPro:IPR019831
InterPro:IPR019832
InterPro:IPR019833

P

Seeded From UniProt

complete

protected

enables

GO:0004784

superoxide dismutase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.15.1.1

F

Seeded From UniProt

complete

protected

enables

GO:0030145

manganese ion binding

PMID:10511315

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005759

mitochondrial matrix

PMID:10511315
Reactome:R-HSA-9617941
Reactome:R-HSA-9617833
Reactome:R-HSA-8870703
Reactome:R-HSA-5688289
Reactome:R-HSA-3299680

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

protected

involved_in

GO:0035722

interleukin-12-mediated signaling pathway

Reactome:R-HSA-9020591

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0034599

cellular response to oxidative stress

Reactome:R-HSA-3299685

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

protected

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

protected

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

protected

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete




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