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PMID:12175485
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| Citation |
Ohshiro, T, Emori, Y and Saigo, K (2002) Ligand-dependent activation of breathless FGF receptor gene in Drosophila developing trachea. Mech. Dev. 114:3-11 |
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| Abstract |
Spatially and temporally regulated activity of Branchless/Breathless signaling is essential for trachea development in Drosophila. Early ubiquitous breathless (btl) expression is controlled by binding of Trachealess/Tango heterodimers to the btl minimum enhancer. Branchless/Breathless signaling includes a Sprouty-dependent negative feedback loop. We show that late btl expression is a target of Branchless/Breathless signaling and hence, Branchless/Breathless signaling contains a positive feedback loop, which may guarantee a continuous supply of fresh receptors to membranes of growing tracheal branch cells. Branchless/Breathless signaling activates MAP-kinase, which in turn, activates late btl expression and destabilizes Anterior-open, a repressor for late btl expression. Biochemical and genetic analysis indicated that the minimum btl enhancer includes binding sites of Anterior-open. |
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| Keywords |
Animals; Base Sequence; Drosophila/embryology; Drosophila Proteins/metabolism; Eye Proteins/metabolism; Gene Expression Regulation, Developmental; Immunohistochemistry; Ligands; MAP Kinase Signaling System; Models, Genetic; Molecular Sequence Data; Mutagenesis; Plasmids/metabolism; Polymerase Chain Reaction; Protein-Tyrosine Kinases; RNA/metabolism; Receptors, Fibroblast Growth Factor/metabolism; Repressor Proteins/metabolism; Signal Transduction; Trachea/embryology; Transcription, Genetic |
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