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HUMAN:UCP2

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0001666

response to hypoxia

PMID:22292025

ECO:0000314

P

Fig 1B - UCP2 levels increase as levels of hypoxia increase

complete
CACAO 3759

public

GO:0006915

apoptotic process

PMID:22292025

ECO:0000314

P

Fig 3A overexpression of UCP2 under hypoxic conditions decreases levels of apoptosis

complete
CACAO 3760

protected

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

PMID:28130074

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P70406

P

Seeded From UniProt

complete

protected

involved_in

GO:0001666

response to hypoxia

PMID:22292025

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005743

mitochondrial inner membrane

PMID:9196039

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:1990845

adaptive thermogenesis

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98894
PANTHER:PTN002378102

P

Seeded From UniProt

complete

protected

involved_in

GO:1990542

mitochondrial transmembrane transport

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98894
PANTHER:PTN000642156
RGD:3931

P

Seeded From UniProt

complete

protected

enables

GO:0017077

oxidative phosphorylation uncoupler activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1099787
MGI:MGI:98894
PANTHER:PTN000642156
RGD:3931
TAIR:locus:2080300

F

Seeded From UniProt

complete

protected

involved_in

GO:0009409

response to cold

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002378102
RGD:3933

P

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0097421

liver regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

involved_in

GO:0071333

cellular response to glucose stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

involved_in

GO:0070542

response to fatty acid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

involved_in

GO:0061179

negative regulation of insulin secretion involved in cellular response to glucose stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

involved_in

GO:0034198

cellular response to amino acid starvation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

involved_in

GO:0032870

cellular response to hormone stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

involved_in

GO:0032869

cellular response to insulin stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

involved_in

GO:0010942

positive regulation of cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

involved_in

GO:0009749

response to glucose

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

involved_in

GO:0007565

female pregnancy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

involved_in

GO:0006839

mitochondrial transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

C

Seeded From UniProt

complete

protected

involved_in

GO:0001666

response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

involved_in

GO:0000303

response to superoxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

protected

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70406
ensembl:ENSMUSP00000120967

P

Seeded From UniProt

complete

protected

involved_in

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70406
ensembl:ENSMUSP00000120967

P

Seeded From UniProt

complete

protected

involved_in

GO:0006839

mitochondrial transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002030

P

Seeded From UniProt

complete

protected

enables

GO:0022857

transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040062

F

Seeded From UniProt

complete

protected

part_of

GO:0031966

mitochondrial membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002030

C

Seeded From UniProt

complete

protected

involved_in

GO:1902600

proton transmembrane transport

PMID:9054939
Reactome:R-HSA-167827
Reactome:R-HSA-166187

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

protected

part_of

GO:0005743

mitochondrial inner membrane

Reactome:R-HSA-170026
Reactome:R-HSA-166387
Reactome:R-HSA-166220
Reactome:R-HSA-166214

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

protected

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0999
UniProtKB-SubCell:SL-0168

C

Seeded From UniProt

complete



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