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HUMAN:PP1A

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0016311

dephosphorylation

PMID:22311981

ECO:0000314

P

Figure 8

complete
CACAO 3738

public

GO:0006470

protein dephosphorylation

PMID:22311981

ECO:0000315

P

Figure 5: Knockdown of PP1 and PP2A isoforms in ERM dephosphorylation.

complete
CACAO 5317

protected

part_of

GO:0005913

cell-cell adherens junction

PMID:25468996

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

colocalizes_with

GO:0000784

nuclear chromosome, telomeric region

PMID:24270157

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:1904886

beta-catenin destruction complex disassembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P62139

P

Seeded From UniProt

complete

protected

involved_in

GO:0060828

regulation of canonical Wnt signaling pathway

PMID:17318175

ECO:0000305

curator inference used in manual assertion

GO:0005515

P

Seeded From UniProt

complete

protected

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P62139

F

  • has_direct_input:(UniProtKB:O15169)
  • part_of:(GO:1904886)
  • part_of:(GO:0032091)

Seeded From UniProt

complete

protected

involved_in

GO:0032091

negative regulation of protein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P62139

P

  • has_regulation_target:(UniProtKB:O15169)
  • has_regulation_target:(UniProtKB:P49841)
  • part_of:(GO:1904886)

Seeded From UniProt

complete

protected

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P62139

P

has_direct_input:(UniProtKB:O15169)

Seeded From UniProt

complete

protected

involved_in

GO:0006470

protein dephosphorylation

PMID:22311981

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0098641

cadherin binding involved in cell-cell adhesion

PMID:25468996

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0036496

regulation of translational initiation by eIF2 alpha dephosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P62139

P

Seeded From UniProt

complete

protected

involved_in

GO:0016311

dephosphorylation

PMID:22311981

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0070062

extracellular exosome

PMID:20458337

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21630459

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

protected

involved_in

GO:0010288

response to lead ion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P62138

P

  • occurs_in:(UBERON:0001885)
  • causally_upstream_of:(GO:0007416)
  • causally_upstream_of:(GO:0007611)

Seeded From UniProt

complete

protected

part_of

GO:0072357

PTW/PP1 phosphatase complex

PMID:20516061

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0043153

entrainment of circadian clock by photoperiod

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P62137

P

Seeded From UniProt

complete

protected

involved_in

GO:0042752

regulation of circadian rhythm

PMID:21712997

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032922

circadian regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P62137

P

Seeded From UniProt

complete

protected

enables

GO:0016791

phosphatase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P62137

F

Seeded From UniProt

complete

protected

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P62137

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:11739654

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:11739654

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0043153

entrainment of circadian clock by photoperiod

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103016
MGI:MGI:104872
PANTHER:PTN002617081

P

Seeded From UniProt

complete

protected

involved_in

GO:0042752

regulation of circadian rhythm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103016
MGI:MGI:104872
PANTHER:PTN002617081
UniProtKB:P36873
UniProtKB:P62136

P

Seeded From UniProt

complete

protected

enables

GO:0008157

protein phosphatase 1 binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002617081
RGD:3375
RGD:3377

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003140
MGI:MGI:103016
MGI:MGI:104871
MGI:MGI:104872
PANTHER:PTN000185232
PomBase:SPAC57A7.08
PomBase:SPBC776.02c
PomBase:SPCC31H12.05c
RGD:3375
RGD:3376
RGD:3377
SGD:S000000935
TAIR:locus:2024507
UniProtKB:P36873
UniProtKB:P62136
UniProtKB:P62140
UniProtKB:Q57YU1
UniProtKB:Q583K6
WB:WBGene00001748
WB:WBGene00020187
WB:WBGene00021113

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003140
FB:FBgn0025573
MGI:MGI:103016
PANTHER:PTN000185231
PomBase:SPBC776.02c
PomBase:SPCC31H12.05c
RGD:3375
SGD:S000000935
SGD:S000004478
TAIR:locus:2024507
TAIR:locus:2063942
TAIR:locus:2825042
UniProtKB:P20654
UniProtKB:Q583K6
UniProtKB:Q585J4
UniProtKB:Q59N42
WB:WBGene00001748
WB:WBGene00020187
WB:WBGene00021113

C

Seeded From UniProt

complete

protected

enables

GO:0004722

protein serine/threonine phosphatase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000711
FB:FBgn0003132
FB:FBgn0003140
FB:FBgn0004103
MGI:MGI:103016
MGI:MGI:104871
MGI:MGI:104872
PANTHER:PTN000185232
PomBase:SPAC57A7.08
PomBase:SPBC776.02c
SGD:S000000935
SGD:S000004478
TAIR:locus:2024507
TAIR:locus:2043122
TAIR:locus:2063942
TAIR:locus:2078087
TAIR:locus:2102762
TAIR:locus:2128258
TAIR:locus:2168484
TAIR:locus:2180330
TAIR:locus:2825042
UniProtKB:P36873
UniProtKB:P62207
UniProtKB:Q57YU1
UniProtKB:Q59U06
WB:WBGene00001748

F

Seeded From UniProt

complete

protected

involved_in

GO:0006470

protein dephosphorylation

PMID:22801782

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0098609

cell-cell adhesion

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0098641

P

Seeded From UniProt

complete

protected

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

C

Seeded From UniProt

complete

protected

part_of

GO:0098794

postsynapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

C

Seeded From UniProt

complete

protected

part_of

GO:0098793

presynapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

C

Seeded From UniProt

complete

protected

enables

GO:0044877

protein-containing complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

F

Seeded From UniProt

complete

protected

part_of

GO:0043204

perikaryon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

C

Seeded From UniProt

complete

protected

part_of

GO:0043197

dendritic spine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

C

Seeded From UniProt

complete

protected

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

C

Seeded From UniProt

complete

protected

enables

GO:0043021

ribonucleoprotein complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

F

Seeded From UniProt

complete

protected

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

C

Seeded From UniProt

complete

protected

part_of

GO:0042587

glycogen granule

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

C

Seeded From UniProt

complete

protected

involved_in

GO:0010288

response to lead ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

P

Seeded From UniProt

complete

protected

enables

GO:0008157

protein phosphatase 1 binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

F

Seeded From UniProt

complete

protected

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

P

Seeded From UniProt

complete

protected

involved_in

GO:0005981

regulation of glycogen catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

P

Seeded From UniProt

complete

protected

involved_in

GO:0005979

regulation of glycogen biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

C

Seeded From UniProt

complete

protected

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

F

Seeded From UniProt

complete

protected

part_of

GO:0000164

protein phosphatase type 1 complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62138
ensembl:ENSRNOP00000025282

C

Seeded From UniProt

complete

protected

involved_in

GO:2001241

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62137
ensembl:ENSMUSP00000039109

P

Seeded From UniProt

complete

protected

involved_in

GO:0048754

branching morphogenesis of an epithelial tube

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62137
ensembl:ENSMUSP00000039109

P

Seeded From UniProt

complete

protected

involved_in

GO:0043153

entrainment of circadian clock by photoperiod

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62137
ensembl:ENSMUSP00000039109

P

Seeded From UniProt

complete

protected

involved_in

GO:0042752

regulation of circadian rhythm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62137
ensembl:ENSMUSP00000039109

P

Seeded From UniProt

complete

protected

involved_in

GO:0032922

circadian regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62137
ensembl:ENSMUSP00000039109

P

Seeded From UniProt

complete

protected

involved_in

GO:0030324

lung development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62137
ensembl:ENSMUSP00000039109

P

Seeded From UniProt

complete

protected

enables

GO:0016791

phosphatase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62137
ensembl:ENSMUSP00000039109

F

Seeded From UniProt

complete

protected

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62137
ensembl:ENSMUSP00000039109

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62137
ensembl:ENSMUSP00000039109

C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62137
ensembl:ENSMUSP00000039109

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62137
ensembl:ENSMUSP00000039109

C

Seeded From UniProt

complete

protected

enables

GO:0004722

protein serine/threonine phosphatase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62137
ensembl:ENSMUSP00000039109

F

Seeded From UniProt

complete

protected

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P62137
ensembl:ENSMUSP00000039109

F

Seeded From UniProt

complete

protected

part_of

GO:0000164

protein phosphatase type 1 complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037979

C

Seeded From UniProt

complete

protected

enables

GO:0004722

protein serine/threonine phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037979

F

Seeded From UniProt

complete

protected

enables

GO:0016787

hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004843
InterPro:IPR006186

F

Seeded From UniProt

complete

protected

part_of

GO:0072357

PTW/PP1 phosphatase complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037979

C

Seeded From UniProt

complete

protected

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.16

F

Seeded From UniProt

complete

protected

involved_in

GO:0035970

peptidyl-threonine dephosphorylation

PMID:16262633

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0070262

peptidyl-serine dephosphorylation

PMID:16262633

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0004722

protein serine/threonine phosphatase activity

PMID:16262633
PMID:8392016
PMID:10640627

ECO:0000304

author statement supported by traceable reference used in manual assertion



F

has_direct_input:(UniProtKB:P10636)

Seeded From UniProt

complete

protected

involved_in

GO:0006470

protein dephosphorylation

PMID:8392016

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

Reactome:R-HSA-180038

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

protected

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

protected

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

protected

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

protected

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0119

P

Seeded From UniProt

complete

protected

involved_in

GO:0005977

glycogen metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0321

P

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0190

C

Seeded From UniProt

complete

protected

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete



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