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HUMAN:HDAC3

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0006303

double-strand break repair via nonhomologous end joining

PMID:21075309

ECO:0000315

P

Figure 1, F

complete

protected

involved_in

GO:0032922

circadian regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88895

P

Seeded From UniProt

complete

protected

involved_in

GO:0031398

positive regulation of protein ubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88895

P

Seeded From UniProt

complete

protected

involved_in

GO:0042752

regulation of circadian rhythm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88895

P

Seeded From UniProt

complete

protected

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

PMID:28614293

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O88895

P

Seeded From UniProt

complete

protected

part_of

GO:0000118

histone deacetylase complex

PMID:18326024

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0006476

protein deacetylation

PMID:21030595

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:21030595

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21030595

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0051059

NF-kappaB binding

PMID:17785205

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q04206

F

Seeded From UniProt

complete

protected

enables

GO:0042826

histone deacetylase binding

PMID:23867755

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UQL6

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:25190803

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0032008

positive regulation of TOR signaling

PMID:25190803

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0001934

positive regulation of protein phosphorylation

PMID:25190803

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042307

positive regulation of protein import into nucleus

PMID:25190803

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0031647

regulation of protein stability

PMID:25190803

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:25190803

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0071498

cellular response to fluid shear stress

PMID:25190803

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0042826

histone deacetylase binding

PMID:12590135

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UKV0

F

Seeded From UniProt

complete

protected

enables

GO:0042826

histone deacetylase binding

PMID:10869435

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P56524

F

Seeded From UniProt

complete

protected

enables

GO:0042826

histone deacetylase binding

PMID:10869435

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9UQL6

F

Seeded From UniProt

complete

protected

part_of

GO:0017053

transcriptional repressor complex

PMID:11804585

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

NOT|involved_in

GO:0010832

negative regulation of myotube differentiation

PMID:10983972

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:18347167

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:18854353

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051225

spindle assembly

PMID:18326024

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0046329

negative regulation of JNK cascade

PMID:11931768

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:16924111

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0033558

protein deacetylase activity

PMID:17172643

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0030332

cyclin binding

PMID:18417529

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P24385

F

Seeded From UniProt

complete

protected

enables

GO:0019899

enzyme binding

PMID:11641274

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NWT6

F

Seeded From UniProt

complete

protected

part_of

GO:0017053

transcriptional repressor complex

PMID:18417529

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0017053

transcriptional repressor complex

PMID:16569215

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0017053

transcriptional repressor complex

PMID:12628926

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0008134

transcription factor binding

PMID:16569215

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q01101

F

Seeded From UniProt

complete

protected

involved_in

GO:0006476

protein deacetylation

PMID:17172643

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0072686

mitotic spindle

PMID:18326024

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:18326024

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0004407

histone deacetylase activity

PMID:16924111

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004407

histone deacetylase activity

PMID:18326024

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003714

transcription corepressor activity

PMID:12628926

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003714

transcription corepressor activity

PMID:18417529

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003714

transcription corepressor activity

PMID:16569215

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003682

chromatin binding

PMID:18417529

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003682

chromatin binding

PMID:16569215

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:12628926

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:18417529

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:16569215

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0070933

histone H4 deacetylation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108086
MGI:MGI:1097691
MGI:MGI:1343091
PANTHER:PTN002578320
PomBase:SPAC3G9.07c
SGD:S000005274
SGD:S000006272
UniProtKB:G5EB64
UniProtKB:Q13547

P

Seeded From UniProt

complete

protected

involved_in

GO:0070932

histone H3 deacetylation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108086
MGI:MGI:1097691
PANTHER:PTN002578320
RGD:1309799
RGD:619976
RGD:619977
SGD:S000005274
TAIR:locus:2098115
UniProtKB:G5EB64
UniProtKB:Q13547

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002578320
PomBase:SPBC36.05c
SGD:S000005274
SGD:S000006272
UniProtKB:O15379
UniProtKB:Q13547
UniProtKB:Q92769
WB:WBGene00001834

P

Seeded From UniProt

complete

protected

enables

GO:0004407

histone deacetylase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015805
FB:FBgn0025825
MGI:MGI:108086
MGI:MGI:1097691
PANTHER:PTN002578320
PomBase:SPAC3G9.07c
PomBase:SPBC36.05c
RGD:1309799
SGD:S000003162
SGD:S000005274
TAIR:locus:2162017
UniProtKB:G5EB64
UniProtKB:O15379
UniProtKB:Q13547
UniProtKB:Q7K6A1
UniProtKB:Q92769
WB:WBGene00001834
dictyBase:DDB_G0270338

F

Seeded From UniProt

complete

protected

part_of

GO:0000118

histone deacetylase complex

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015805
MGI:MGI:108086
PANTHER:PTN002578320
PomBase:SPAC3G9.07c
PomBase:SPBC36.05c
SGD:S000003162
SGD:S000005274
SGD:S000006272
UniProtKB:Q13547
UniProtKB:Q92769
WB:WBGene00001834

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005794

Golgi apparatus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0004407

histone deacetylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003084

F

Seeded From UniProt

complete

protected

involved_in

GO:0016575

histone deacetylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003084

P

Seeded From UniProt

complete

protected

enables

GO:0004407

histone deacetylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.1.98

F

Seeded From UniProt

complete

protected

enables

GO:0032041

NAD-dependent histone deacetylase activity (H3-K14 specific)

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.1.98

F

Seeded From UniProt

complete

protected

enables

GO:0003714

transcription corepressor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56520

F

Seeded From UniProt

complete

protected

involved_in

GO:1903507

negative regulation of nucleic acid-templated transcription

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0003714

P

Seeded From UniProt

complete

protected

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:10777477

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:9501169
PMID:12711221

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

protected

enables

GO:0004407

histone deacetylase activity

PMID:10777477
PMID:12711221

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

protected

involved_in

GO:0006325

chromatin organization

PMID:12711221

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008134

transcription factor binding

PMID:12711221

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:12711221

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0000118

histone deacetylase complex

PMID:12711221

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0019216

regulation of lipid metabolic process

Reactome:R-HSA-400206

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007623

circadian rhythm

Reactome:R-HSA-400253

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-5663271
Reactome:R-HSA-5663265
Reactome:R-HSA-5663258
Reactome:R-HSA-5663245
Reactome:R-HSA-400183
Reactome:R-HSA-400143
Reactome:R-HSA-3777129
Reactome:R-HSA-2220982
Reactome:R-HSA-1368069

ECO:0000304

author statement supported by traceable reference used in manual assertion









C

Seeded From UniProt

complete

protected

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

protected

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete



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