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PMID:18488910
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Citation |
Lelevich, SV [Tissue-specific features of the pentose phosphate pathway in rats under acute alcoholic intoxication conditions]. Eksp Klin Farmakol 71:53-5 |
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Abstract |
The activity of pentose phosphate pathway (PPP) in the liver and skeletal muscles of rats has been studied after acute alcohol administration in a dose of 1, 2.5, and 5 g/kg body weight. Inhibition of the activity of the main PPP enzymes as well as a decrease in the liver pentose level in rats as a result of alcohol intoxication have been observed. In muscle tissues, alcohol leads to the activation of glucose-6-phosphate-dehydrogenase and the inhibition of the transketolase activity. |
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Keywords |
Alcoholic Intoxication/enzymology; Animals; Blood Glucose/metabolism; Enzyme Activation; Glucosephosphate Dehydrogenase/metabolism; Insulin/blood; Liver/enzymology; Male; Muscle, Skeletal/enzymology; Organ Specificity; Pentose Phosphate Pathway; Rats |
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