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HUMAN:FADD

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0016265

death

PMID:7538907

ECO:0000316

UniProtKB:P25445 UniProtKB:Q13158


P

Figures 4 and 5

complete
CACAO 3545

public

GO:0031264

PMID:7538907

ECO:0000247

PMID:7538907


Analysis of data using Northern blotting, sequence alignment and expression vectors

complete
CACAO 9344

public

GO:0031264

death-inducing signaling complex

PMID:7536190

ECO:0000315

C

Northern and Sequence Analyses

complete
CACAO 9345

public

GO:0045559

PMID:14702039

ECO:0000314

Sequence analysis

complete
CACAO 9346

public

GO:0031265

PMID:10825539

ECO:0000247

PMID:10825539


Analysis of Sequence ALignment, Figure 2

complete
CACAO 9348

public

GO:0031264

PMID:9582077

ECO:0000247

PMID:958207


Analysis from FIgure 1 Northern blotting, and Figure 3 Sequence Alignment

complete
CACAO 9349

protected

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:11821383

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0089720

caspase binding

PMID:9343261

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q14790

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:22510408

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:22510408

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0036462

TRAIL-activated apoptotic signaling pathway

PMID:21785459

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:21785459

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0002020

protease binding

PMID:21785459

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q14790

F

Seeded From UniProt

complete

protected

involved_in

GO:0097527

necroptotic signaling pathway

PMID:11101870

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0097202

activation of cysteine-type endopeptidase activity

PMID:18387192

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0097190

apoptotic signaling pathway

PMID:11101870

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:16127453

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045862

positive regulation of proteolysis

PMID:18387192

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032760

positive regulation of tumor necrosis factor production

PMID:16127453

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032757

positive regulation of interleukin-8 production

PMID:16127453

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0031264

death-inducing signaling complex

PMID:11101870

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:2001238

positive regulation of extrinsic apoptotic signaling pathway

PMID:21525013

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_input:(GO:0031264)

Seeded From UniProt

complete

protected

involved_in

GO:2000454

positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61160

P

Seeded From UniProt

complete

protected

part_of

GO:0097342

ripoptosome

PMID:21737330

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0097191

extrinsic apoptotic signaling pathway

PMID:16611992

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0097191

extrinsic apoptotic signaling pathway

PMID:21785459

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0071260

cellular response to mechanical stimulus

PMID:19593445

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0070236

negative regulation of activation-induced cell death of T cells

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61160

P

Seeded From UniProt

complete

protected

involved_in

GO:0060340

positive regulation of type I interferon-mediated signaling pathway

PMID:21109225

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051607

defense response to virus

PMID:21109225

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048538

thymus development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61160

P

Seeded From UniProt

complete

protected

involved_in

GO:0048536

spleen development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61160

P

Seeded From UniProt

complete

protected

involved_in

GO:0048535

lymph node development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61160

P

Seeded From UniProt

complete

protected

involved_in

GO:0045651

positive regulation of macrophage differentiation

PMID:17047155

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:12761501

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:20935634

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043029

T cell homeostasis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61160

P

Seeded From UniProt

complete

protected

involved_in

GO:0042104

positive regulation of activated T cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61160

P

Seeded From UniProt

complete

protected

enables

GO:0035877

death effector domain binding

PMID:11717445

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q14790

F

Seeded From UniProt

complete

protected

enables

GO:0035877

death effector domain binding

PMID:11717445

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q92851

F

Seeded From UniProt

complete

protected

involved_in

GO:0033077

T cell differentiation in thymus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61160

P

Seeded From UniProt

complete

protected

enables

GO:0032813

tumor necrosis factor receptor superfamily binding

PMID:21109225

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P25445

F

Seeded From UniProt

complete

protected

involved_in

GO:0032729

positive regulation of interferon-gamma production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61160

P

Seeded From UniProt

complete

protected

part_of

GO:0031265

CD95 death-inducing signaling complex

PMID:20935634

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0031264

death-inducing signaling complex

PMID:21803845

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0006915

apoptotic process

PMID:22891283

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0002821

positive regulation of adaptive immune response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61160

P

Seeded From UniProt

complete

protected

enables

GO:0002020

protease binding

PMID:9208847

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q14790

F

Seeded From UniProt

complete

protected

involved_in

GO:0001916

positive regulation of T cell mediated cytotoxicity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61160

P

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:8681376

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13158

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:7536190

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13158

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:30561431

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13158

F

Seeded From UniProt

complete

protected

involved_in

GO:2001238

positive regulation of extrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:2000454

positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0097191

extrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0097049

motor neuron apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0070236

negative regulation of activation-induced cell death of T cells

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0060546

negative regulation of necroptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0048538

thymus development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0048536

spleen development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0048535

lymph node development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0043029

T cell homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0042104

positive regulation of activated T cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0033077

T cell differentiation in thymus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0032729

positive regulation of interferon-gamma production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0002821

positive regulation of adaptive immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0001916

positive regulation of T cell mediated cytotoxicity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61160
ensembl:ENSMUSP00000033394

P

Seeded From UniProt

complete

protected

involved_in

GO:0060544

regulation of necroptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

P

Seeded From UniProt

complete

protected

involved_in

GO:0048148

behavioral response to cocaine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

P

Seeded From UniProt

complete

protected

part_of

GO:0045121

membrane raft

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

C

Seeded From UniProt

complete

protected

enables

GO:0044877

protein-containing complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

F

Seeded From UniProt

complete

protected

part_of

GO:0044297

cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

C

Seeded From UniProt

complete

protected

involved_in

GO:0043278

response to morphine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

P

Seeded From UniProt

complete

protected

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

C

Seeded From UniProt

complete

protected

involved_in

GO:0042220

response to cocaine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

P

Seeded From UniProt

complete

protected

enables

GO:0033612

receptor serine/threonine kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

F

Seeded From UniProt

complete

protected

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

C

Seeded From UniProt

complete

protected

part_of

GO:0031265

CD95 death-inducing signaling complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

C

Seeded From UniProt

complete

protected

part_of

GO:0031264

death-inducing signaling complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

C

Seeded From UniProt

complete

protected

enables

GO:0005164

tumor necrosis factor receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

F

Seeded From UniProt

complete

protected

enables

GO:0005123

death receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

F

Seeded From UniProt

complete

protected

enables

GO:0002020

protease binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

F

Seeded From UniProt

complete

protected

involved_in

GO:0001822

kidney development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R2E7
ensembl:ENSRNOP00000066289

P

Seeded From UniProt

complete

protected

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000488

P

Seeded From UniProt

complete

protected

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001875

P

Seeded From UniProt

complete

protected

involved_in

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

PMID:7538907

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0005123

death receptor binding

PMID:7538907

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0097191

extrinsic apoptotic signaling pathway

PMID:18309324

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0031264

death-inducing signaling complex

PMID:18309324

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Reactome:R-HSA-5675456
Reactome:R-HSA-3465429

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

protected

involved_in

GO:1902041

regulation of extrinsic apoptotic signaling pathway via death domain receptors

Reactome:R-HSA-3371378

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0097190

apoptotic signaling pathway

Reactome:R-HSA-9013895
Reactome:R-HSA-75157
Reactome:R-HSA-2562564

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

protected

involved_in

GO:0071550

death-inducing signaling complex assembly

Reactome:R-HSA-5357786

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035666

TRIF-dependent toll-like receptor signaling pathway

Reactome:R-HSA-937061

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0034138

toll-like receptor 3 signaling pathway

Reactome:R-HSA-168164

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007166

cell surface receptor signaling pathway

Reactome:R-HSA-73887

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

Reactome:R-HSA-69416

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

Reactome:R-HSA-933539
Reactome:R-HSA-933532
Reactome:R-HSA-933526
Reactome:R-HSA-933523
Reactome:R-HSA-9013895
Reactome:R-HSA-9013889
Reactome:R-HSA-83650
Reactome:R-HSA-83586
Reactome:R-HSA-75240
Reactome:R-HSA-75187
Reactome:R-HSA-75146
Reactome:R-HSA-73945
Reactome:R-HSA-5675456
Reactome:R-HSA-3465459
Reactome:R-HSA-3465448
Reactome:R-HSA-3465429
Reactome:R-HSA-3371360
Reactome:R-HSA-3371359
Reactome:R-HSA-2562564
Reactome:R-HSA-2562541
Reactome:R-HSA-168934
Reactome:R-HSA-141316
Reactome:R-HSA-141310
Reactome:R-HSA-141159
Reactome:R-HSA-141156
Reactome:R-HSA-140978
Reactome:R-HSA-139952

ECO:0000304

author statement supported by traceable reference used in manual assertion



























C

Seeded From UniProt

complete

protected

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

protected

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

protected

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

protected

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete



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