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HUMAN:NRX1B

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

protected

involved_in

GO:0045743

positive regulation of fibroblast growth factor receptor signaling pathway

PMID:22750515

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P11362)

Seeded From UniProt

complete

protected

enables

GO:0005105

type 1 fibroblast growth factor receptor binding

PMID:22750515

ECO:0000314

direct assay evidence used in manual assertion

F

positively_regulates:(GO:0018108)

Seeded From UniProt

complete

protected

involved_in

GO:0031175

neuron projection development

PMID:22750515

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q62765

P

occurs_in:(CL:0002608)

Seeded From UniProt

complete

protected

involved_in

GO:0071277

cellular response to calcium ion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63373

P

Seeded From UniProt

complete

protected

enables

GO:0097109

neuroligin family protein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63373

F

part_of:(GO:0071277)

Seeded From UniProt

complete

protected

enables

GO:0097109

neuroligin family protein binding

PMID:14522992

ECO:0000303

author statement without traceable support used in manual assertion

F

  • occurs_in:(GO:0045202)
  • occurs_in:(GO:0005615)

Seeded From UniProt

complete

protected

part_of

GO:0098793

presynapse

PMID:14522992

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0051897

positive regulation of protein kinase B signaling

PMID:26078884

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0002609)

Seeded From UniProt

complete

protected

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:26078884

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0002609)

Seeded From UniProt

complete

protected

involved_in

GO:0010739

positive regulation of protein kinase A signaling

PMID:26078884

ECO:0000314

direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:Q05586)
  • regulates_o_occurs_in:(CL:0002609)

Seeded From UniProt

complete

protected

involved_in

GO:1900020

positive regulation of protein kinase C activity

PMID:26078884

ECO:0000314

direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:Q05586)
  • regulates_o_occurs_in:(CL:0002609)

Seeded From UniProt

complete

protected

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

PMID:26078884

ECO:0000314

direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:Q05586)
  • regulates_o_occurs_in:(CL:0002609)
  • regulates:(GO:0004697)
  • regulates:(GO:0010737)

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:26078884

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSG00000136238)
  • regulates_o_occurs_in:(CL:0002609)|regulates_expression_of(ENSEMBL:ENSG00000170345)
  • regulates_o_occurs_in:(CL:0002609)|regulates_expression_of(ENSEMBL:ENSG00000176884)
  • regulates_o_occurs_in:(CL:0002609)

Seeded From UniProt

complete

protected

involved_in

GO:0010629

negative regulation of gene expression

PMID:26078884

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_expression_of:(ENSEMBL:ENSG00000162946)

Seeded From UniProt

complete

protected

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

F

Seeded From UniProt

complete

protected

involved_in

GO:0007165

signal transduction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

part_of

GO:0043025

neuronal cell body

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

C

part_of:(CL:1001571)

Seeded From UniProt

complete

protected

part_of

GO:0042734

presynaptic membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

C

part_of:(UBERON:0014554)

Seeded From UniProt

complete

protected

part_of

GO:0042734

presynaptic membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

C

part_of:(CL:1001571)

Seeded From UniProt

complete

protected

part_of

GO:0031982

vesicle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

C

  • part_of:(CL:1001571)
  • part_of:(GO:0043025)

Seeded From UniProt

complete

protected

part_of

GO:0031965

nuclear membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

C

  • part_of:(CL:1001571)
  • part_of:(GO:0043025)

Seeded From UniProt

complete

protected

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

C

  • part_of:(CL:1001571)
  • part_of:(GO:0043025)

Seeded From UniProt

complete

protected

involved_in

GO:0090126

protein-containing complex assembly involved in synapse maturation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:2000463

positive regulation of excitatory postsynaptic potential

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:2000311

regulation of AMPA receptor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:2000310

regulation of NMDA receptor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0097120

receptor localization to synapse

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0097119

postsynaptic density protein 95 clustering

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0097118

neuroligin clustering involved in postsynaptic membrane assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0097117

guanylate kinase-associated protein clustering

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0097116

gephyrin clustering involved in postsynaptic density assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0097114

NMDA glutamate receptor clustering

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0097112

gamma-aminobutyric acid receptor clustering

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

enables

GO:0097109

neuroligin family protein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

F

Seeded From UniProt

complete

protected

involved_in

GO:0097105

presynaptic membrane assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0097104

postsynaptic membrane assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0097091

synaptic vesicle clustering

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:1903078

positive regulation of protein localization to plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0071625

vocalization behavior

PMID:17034946

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051968

positive regulation of synaptic transmission, glutamatergic

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0051490

negative regulation of filopodium assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

enables

GO:0050839

cell adhesion molecule binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

F

Seeded From UniProt

complete

protected

enables

GO:0050839

cell adhesion molecule binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63373

F

Seeded From UniProt

complete

protected

enables

GO:0048306

calcium-dependent protein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

F

Seeded From UniProt

complete

protected

involved_in

GO:0045184

establishment of protein localization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

part_of

GO:0044295

axonal growth cone

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

C

Seeded From UniProt

complete

protected

involved_in

GO:0035418

protein localization to synapse

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0035176

social behavior

PMID:17034946

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030534

adult behavior

PMID:17034946

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0030139

endocytic vesicle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63373

C

Seeded From UniProt

complete

protected

involved_in

GO:0021707

cerebellar granule cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0016339

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

part_of

GO:0009986

cell surface

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63373

C

Seeded From UniProt

complete

protected

involved_in

GO:0007612

learning

PMID:17034946

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007416

synapse assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0007158

neuron cell-cell adhesion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

involved_in

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0DI97

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63373

C

Seeded From UniProt

complete

protected

enables

GO:0005102

signaling receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63373

F

Seeded From UniProt

complete

protected

involved_in

GO:0001525

angiogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:D0PRN2

P

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037440

C

Seeded From UniProt

complete

protected

part_of

GO:0099056

integral component of presynaptic membrane

PMID:15797875

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0051965

positive regulation of synapse assembly

PMID:15797875

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1905520

positive regulation of presynaptic active zone assembly

PMID:15797875

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0042734

presynaptic membrane

PMID:15797875

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0023041

neuronal signal transduction

PMID:15797875

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007158

neuron cell-cell adhesion

PMID:15797875

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-6797974
Reactome:R-HSA-6797568
Reactome:R-HSA-6797554
Reactome:R-HSA-6794346

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

protected

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

protected

part_of

GO:0045202

synapse

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770

C

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

protected

involved_in

GO:0001525

angiogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0037

P

Seeded From UniProt

complete

protected

part_of

GO:0042734

presynaptic membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0222

C

Seeded From UniProt

complete



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