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TableEdit
HUMAN:PAQRA
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Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status | |
---|---|---|---|---|---|---|---|---|---|---|---|
public |
GO:0045860 |
positive regulation of protein kinase activity |
PMID:21968647 |
ECO:0000314 |
P |
In HEK293T cells, overexpression of PAQR10 or PAQR11 dose-dependently increased the phosphorylation of ERK (Figure 1C). …the phosphorylation levels of ERK and p90RSK, a cytosolic target of ERK [40], were markedly reduced when both PAQR10 and PAQR11 were silenced (Figure 4A). |
complete | ||||
public |
GO:0046579 |
positive regulation of Ras protein signal transduction |
PMID:21968647 |
ECO:0000314 |
P |
We also examined the expression levels of a few target genes downstream of ERK signaling, including c-Fos, JunB and Egr-1 . Consistently, overexpression of PAQR10 elevated the expression levels of these genes in a dose-dependent manner (Figure 1Ewe found that PAQR10-activated ERK phosphorylation was abrogated by inhibitors that were specific for the Ras signaling cascade (Figure 1F). The PAQR10- induced transcription of Egr-1 was blocked by GFPRBD and PD98059 (Supplementary information, Figure S5 and 7B). |
complete | ||||
public |
GO:0032880 |
regulation of protein localization |
PMID:21968647 |
ECO:0000314 |
P |
when coexpressed with Flag-tagged PAQR10 or PAQR11, the localization of HRas in the Golgi apparatus was significantly increased with a clear colocalization with PAQR10/PAQR11 and Golgin-97 (Figure 2A). Overexpression of PAQR10/PAQR11 also markedly increased Golgi localization of NRas and KRas4A (Figure2B and 2C). In MDCK cells, PAQR10 also elevated Golgi localization of HRas, NRas and KRas4A, but not KRas4B (Supplementary information, Figure S7). (summarized in Figure 2E). |
complete | ||||
public |
GO:0004672 |
protein kinase activity |
PMID:21968647 |
ECO:0000314 |
F |
In HEK293T cells, overexpression of PAQR10 or PAQR11 dose-dependently increased the phosphorylation of ERK (Figure 1C). |
complete | ||||
public |
GO:0045666 |
positive regulation of neuron differentiation |
PMID:21968647 |
ECO:0000314 |
P |
When PAQR10 or PAQR11 was expressed in PC12 cells, either of them could significantly stimulate neurite outgrowth (Figure 7), a marker of PC12 cell differentiation. |
complete | ||||
protected |
involved_in |
GO:0045666 |
positive regulation of neuron differentiation |
PMID:21968647 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0004672 |
protein kinase activity |
PMID:21968647 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0032880 |
regulation of protein localization |
PMID:21968647 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0046579 |
positive regulation of Ras protein signal transduction |
PMID:21968647 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0045860 |
positive regulation of protein kinase activity |
PMID:21968647 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
PMID:22500632 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0006468 |
protein phosphorylation |
GO_REF:0000108 |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004672 |
P |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0016021 |
integral component of membrane |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR004254 |
C |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0016020 |
membrane |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0472 |
C |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005794 |
Golgi apparatus |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0333 |
C |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0016021 |
integral component of membrane |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0812 |
C |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0000139 |
Golgi membrane |
GO_REF:0000039 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-SubCell:SL-0134 |
C |
Seeded From UniProt |
complete |
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