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PMID:15118123
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| Citation |
Fremeau, RT Jr, Kam, K, Qureshi, T, Johnson, J, Copenhagen, DR, Storm-Mathisen, J, Chaudhry, FA, Nicoll, RA and Edwards, RH (2004) Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science 304:1815-9 |
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| Abstract |
Vesicular glutamate transporters (VGLUTs) 1 and 2 show a mutually exclusive distribution in the adult brain that suggests specialization for synapses with different properties of release. Consistent with this distribution, inactivation of the VGLUT1 gene silenced a subset of excitatory neurons in the adult. However, the same cell populations exhibited VGLUT1-independent transmission early in life. Developing hippocampal neurons transiently coexpressed VGLUT2 and VGLUT1 at distinct synaptic sites with different short-term plasticity. The loss of VGLUT1 also reduced the reserve pool of synaptic vesicles. Thus, VGLUT1 plays an unanticipated role in membrane trafficking at the nerve terminal. |
| Links |
PubMed Online version:10.1126/science.1097468 |
| Keywords |
Animals; Animals, Newborn; Brain/cytology; Brain/metabolism; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cell Membrane/physiology; Cells, Cultured; Cerebellum/metabolism; Cerebellum/ultrastructure; Excitatory Postsynaptic Potentials; Glutamic Acid/metabolism; Hippocampus/cytology; Hippocampus/metabolism; Hippocampus/ultrastructure; In Situ Hybridization; Membrane Transport Proteins; Mice; Mice, Knockout; Nerve Tissue Proteins/metabolism; Neurons/metabolism; Neurons/physiology; Patch-Clamp Techniques; Purkinje Cells/physiology; Pyramidal Cells/metabolism; Synapses/metabolism; Synapses/ultrastructure; Synaptic Transmission; Synaptic Vesicles/metabolism; Synaptic Vesicles/physiology; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2; Vesicular Transport Proteins |
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