GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

TableEdit

Jump to: navigation, search

PMID:21395886

You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor

Citation

Lai, Z, Wang, F, Zheng, Z, Fan, B and Chen, Z (2011) A critical role of autophagy in plant resistance to necrotrophic fungal pathogens. Plant J. 66:953-68

Abstract

Autophagy is a pathway for degradation of cytoplasmic components. In plants, autophagy plays an important role in nutrient recycling during nitrogen or carbon starvation, and in responses to abiotic stress. Autophagy also regulates age- and immunity-related programmed cell death, which is important in plant defense against biotrophic pathogens. Here we show that autophagy plays a critical role in plant resistance to necrotrophic pathogens. ATG18a, a critical autophagy protein in Arabidopsis, interacts with WRKY33, a transcription factor that is required for resistance to necrotrophic pathogens. Expression of autophagy genes and formation of autophagosomes are induced in Arabidopsis by the necrotrophic fungal pathogen Botrytis cinerea. Induction of ATG18a and autophagy by B. cinerea was compromised in the wrky33 mutant, which is highly susceptible to necrotrophic pathogens. Arabidopsis mutants defective in autophagy exhibit enhanced susceptibility to the necrotrophic fungal pathogens B. cinerea and Alternaria brassicicola based on increased pathogen growth in the mutants. The hypersusceptibility of the autophagy mutants was associated with reduced expression of the jasmonate-regulated PFD1.2 gene, accelerated development of senescence-like chlorotic symptoms, and increased protein degradation in infected plant tissues. These results strongly suggest that autophagy cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens.

Links

PubMed Online version:10.1111/j.1365-313X.2011.04553.x

Keywords

Arabidopsis/genetics; Arabidopsis/immunology; Arabidopsis/metabolism; Arabidopsis/microbiology; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; Autophagy; Binding Sites; Botrytis/immunology; Botrytis/pathogenicity; Cyclopentanes/metabolism; Disease Susceptibility/microbiology; Fluorescence; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Reporter; Immunity, Innate; Oxylipins/metabolism; Plant Diseases/immunology; Plant Diseases/microbiology; Plant Leaves/metabolism; Plants, Genetically Modified/genetics; Plants, Genetically Modified/immunology; Plants, Genetically Modified/metabolism; Plants, Genetically Modified/microbiology; Promoter Regions, Genetic; Recombinant Fusion Proteins/metabolism; Signal Transduction; Transcription Factors/genetics; Transcription Factors/metabolism; Two-Hybrid System Techniques

public



Cancel