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PMID:19458328
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| Citation |
Skarie, JM and Link, BA (2009) FoxC1 is essential for vascular basement membrane integrity and hyaloid vessel morphogenesis. Invest. Ophthalmol. Vis. Sci. 50:5026-34 |
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| Abstract |
Alterations in FOXC1 dosage lead to a spectrum of highly penetrant, ocular anterior segment dysgenesis phenotypes. The most serious outcome is the development of glaucoma, which occurs in 50% to 75% of patients. Therefore, the need to identify specific pathways and genes that interact with FOXC1 to promote glaucoma is great. In this study, the authors investigated the loss of foxC1 in the zebrafish to characterize phenotypes and gene interactions that may impact glaucoma pathogenesis. |
| Links |
PubMed Online version:10.1167/iovs.09-3447 |
| Keywords |
Animals; Basement Membrane/blood supply; Basement Membrane/metabolism; Basement Membrane/pathology; Biological Markers/metabolism; Endothelium, Vascular/metabolism; Endothelium, Vascular/pathology; Eye/embryology; Fluorescein Angiography; Fluorescent Antibody Technique, Indirect; Forkhead Transcription Factors/physiology; Gene Expression; Gene Knockout Techniques; Gene Silencing; In Situ Hybridization; Laminin/metabolism; Lens, Crystalline/blood supply; Microscopy, Confocal; Microscopy, Electron, Transmission; Morphogenesis/physiology; Ophthalmic Artery/embryology; Ophthalmic Artery/metabolism; Ophthalmic Artery/pathology; Zebrafish/embryology; Zebrafish Proteins/metabolism; Zebrafish Proteins/physiology |
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