GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
TableEdit
PMID:17541406
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
See Help for Help on this wiki. See the documentation for how to use the table editor
| Citation |
Pilo Boyl, P, Di Nardo, A, Mulle, C, Sassoè-Pognetto, M, Panzanelli, P, Mele, A, Kneussel, M, Costantini, V, Perlas, E, Massimi, M, Vara, H, Giustetto, M and Witke, W (2007) Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior. EMBO J. 26:2991-3002 |
|---|---|
| Abstract |
Profilins are actin binding proteins essential for regulating cytoskeletal dynamics, however, their function in the mammalian nervous system is unknown. Here, we provide evidence that in mouse brain profilin1 and profilin2 have distinct roles in regulating synaptic actin polymerization with profilin2 preferring a WAVE-complex-mediated pathway. Mice lacking profilin2 show a block in synaptic actin polymerization in response to depolarization, which is accompanied by increased synaptic excitability of glutamatergic neurons due to higher vesicle exocytosis. These alterations in neurotransmitter release correlate with a hyperactivation of the striatum and enhanced novelty-seeking behavior in profilin2 mutant mice. Our results highlight a novel, profilin2-dependent pathway, regulating synaptic physiology, neuronal excitability, and complex behavior. |
| Links |
PubMed PMC1894775 Online version:10.1038/sj.emboj.7601737 |
| Keywords |
Animals; Behavior, Animal/physiology; Exocytosis/physiology; Learning; Long-Term Potentiation; Memory; Mice; Neurons/physiology; Profilins/physiology |
| public |
| Cancel |
