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PMID:16249387
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| Citation |
Ahn, E, Lee, H and Yun, Y (2006) LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation. Blood 107:1521-7 |
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| Abstract |
Assembly of a signaling complex around the transmembrane adapter LAT is essential for the transmission of T-cell receptor (TCR)-mediated signaling. However, a LAT-like molecule responsible for the initial activation events in B-cell receptor (BCR) signaling has not yet been identified. Here, we show that LIME is a transmembrane adaptor required for BCR-mediated B-cell activation. LIME was found to be expressed in mouse splenic B cells. Upon BCR cross-linking, LIME was tyrosine phosphorylated by Lyn and associated with Lyn, Grb2, PLC-gamma2, and PI3K. Reduction of LIME expression by the introduction of siRNA resulted in the disruption of BCR-mediated activation of MAPK, calcium flux, NF-AT, PI3K, and NF-kappaB. Taken together, these results establish that LIME is an essential transmembrane adaptor linking BCR ligation to the downstream signaling events that lead to B-cell activation. |
| Links |
PubMed Online version:10.1182/blood-2005-05-1859 |
| Keywords |
Adaptor Proteins, Vesicular Transport/immunology; Animals; B-Lymphocytes/immunology; Base Sequence; DNA Primers; Lymphocyte Activation; Mice; Plasmids; RNA, Small Interfering/genetics; Receptors, Antigen, T-Cell/immunology; Signal Transduction/immunology; Transfection |
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