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PMID:20875417
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| Citation |
Maheshwari, A, Kelly, DR, Nicola, T, Ambalavanan, N, Jain, SK, Murphy-Ullrich, J, Athar, M, Shimamura, M, Bhandari, V, Aprahamian, C, Dimmitt, RA, Serra, R and Ohls, RK (2011) TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine. Gastroenterology 140:242-53 |
|---|---|
| Abstract |
Premature neonates are predisposed to necrotizing enterocolitis (NEC), an idiopathic, inflammatory bowel necrosis. We investigated whether NEC occurs in the preterm intestine due to incomplete noninflammatory differentiation of intestinal macrophages, which increases the risk of a severe mucosal inflammatory response to bacterial products. |
| Links |
PubMed PMC3008335 Online version:10.1053/j.gastro.2010.09.043 |
| Keywords |
Adult; Animals; Cells, Cultured; Chemotaxis, Leukocyte; Cytokines/metabolism; Enterocolitis, Necrotizing/immunology; Humans; Infant, Newborn; Intestines/growth & development; Intestines/immunology; Lipopolysaccharides/metabolism; Macrophage Activation; Macrophages/metabolism; Mice; Mice, Transgenic; NF-kappa B/metabolism; Neutrophils/metabolism; Transforming Growth Factor beta2/metabolism; Transforming Growth Factor beta2/pharmacology |
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