GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
TableEdit
PMID:20018240
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
See Help for Help on this wiki. See the documentation for how to use the table editor
Citation |
Medici, D and Nawshad, A (2010) Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-kappaB and LEF-1. Matrix Biol. 29:161-5 |
---|---|
Abstract |
Collagen I has been shown to promote epithelial-mesenchymal transition (EMT), a critical process of embryonic development and disease progression. However, little is known about the signaling mechanisms by which collagen I induces this cellular transformation. Here we show that collagen I causes ILK-dependent phosphorylation of IkappaB and subsequent nuclear translocation of active NF-kappaB, which in turn promotes increased expression of the Snail and LEF-1 transcription factors. ILK also causes inhibitory phosphorylation of GSK-3beta, a kinase that prevents functional activation of both Snail and LEF-1. These transcription factors alter expression of epithelial and mesenchymal markers to initiate EMT and stimulate cell migration. These data provide a foundation for understanding the mechanisms by which collagen I stimulates EMT and identify potential therapeutic targets for suppressing this transition in pathological conditions. |
Links |
PubMed PMC2849845 Online version:10.1016/j.matbio.2009.12.003 |
Keywords |
Cell Line, Tumor; Cell Movement/physiology; Collagen Type I/physiology; Epithelial Cells/metabolism; Epithelial Cells/pathology; Extracellular Matrix/physiology; Humans; Immunoblotting; Immunohistochemistry; Lymphoid Enhancer-Binding Factor 1/genetics; Lymphoid Enhancer-Binding Factor 1/physiology; Mesoderm/metabolism; Mesoderm/pathology; NF-kappa B/genetics; NF-kappa B/physiology; Phosphorylation; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/physiology; RNA, Small Interfering/administration & dosage; RNA, Small Interfering/genetics; Transcription Factors/genetics; Transcription Factors/physiology |
public |
Cancel |