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PMID:10766846
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Citation |
Konishi, M, Mikami, T, Yamasaki, M, Miyake, A and Itoh, N (2000) Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes. J. Biol. Chem. 275:12119-22 |
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Abstract |
In rat embryos, fibroblast growth factor (FGF)-16 is predominantly expressed in brown adipose tissue. To elucidate the role of FGF-16, we examined the expression of FGF-16 mRNA in rat embryonic brown adipose tissue at different developmental stages by Northern blotting analysis and in situ hybridization. FGF-16 mRNA was expressed abundantly in brown adipose tissue during embryonic day 17. 5, embryonic days 17.5-19.5, and thereafter at lower levels into the neonatal period. The expression profile of FGF-16 mRNA well corresponds to the proliferative profile of embryonic brown adipose tissue reported. We also examined the mitogenic activity of recombinant rat FGF-16 for primary brown adipocytes prepared from rat embryonic brown adipose tissue. FGF-16 showed significant mitogenic activity for primary brown adipocytes. The mitogenic activity was found to be exerted by binding and activating FGF receptor-4 in the brown adipose tissue. As a great induction of proliferation of rat brown adipose tissue during cold acclimation was reported, we also examined the expression of FGF-16 mRNA in the brown adipose tissue during cold acclimation by Northern blotting analysis. The expression of FGF-16 mRNA was not increased, but rather decreased. The expression profile of FGF-16 mRNA and the mitogenic activity of FGF-16 reported here indicate that FGF-16 is a unique growth factor involved in proliferation of embryonic brown adipose tissue. |
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Keywords |
Adipose Tissue, Brown/embryology; Animals; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cell Division; Cold Temperature; Fibroblast Growth Factors/physiology; In Situ Hybridization; Ion Channels; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mitochondrial Proteins; RNA, Messenger/metabolism; Rats; Rats, Wistar; Uncoupling Agents/metabolism |
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