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PMID:18281244
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| Citation |
Kristensen, DM, Nielsen, JE, Skakkebaek, NE, Graem, N, Jacobsen, GK, Rajpert-De Meyts, E and Leffers, H (2008) Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. Hum. Reprod. 23:775-82 |
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| Abstract |
UTF-1 and REX-1/ZFP42 are transcription factors involved in pluripotency. Because of phenotypic similarities between pluripotent embryonic stem cells and testicular germ cell tumours (TGCT) and the derivation of pluripotent cells from testes, we investigated the expression of UTF-1 and REX-1 during human gonadal development and in TGCT. |
| Links |
PubMed Online version:10.1093/humrep/den010 |
| Keywords |
Child; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Gestational Age; Humans; Immunohistochemistry; In Situ Hybridization; Infant; Kruppel-Like Transcription Factors/biosynthesis; Male; Neoplasms, Germ Cell and Embryonal/metabolism; Nuclear Proteins/biosynthesis; Ovary/metabolism; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; Testis/metabolism; Trans-Activators/biosynthesis |
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