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PMID:11179213
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| Citation |
Cantalupo, G, Alifano, P, Roberti, V, Bruni, CB and Bucci, C (2001) Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. EMBO J. 20:683-93 |
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| Abstract |
Rab7 is a small GTPase that controls transport to endocytic degradative compartments. Here we report the identification of a novel 45 kDa protein that specifically binds Rab7GTP at its C-terminus. This protein contains a domain comprising two coiled-coil regions typical of myosin-like proteins and is found mainly in the cytosol. We named it RILP (Rab-interacting lysosomal protein) since it can be recruited efficiently on late endosomal and lysosomal membranes by Rab7GTP. RILP-C33 (a truncated form of the protein lacking the N-terminal half) strongly inhibits epidermal growth factor and low-density lipoprotein degradation, and causes dispersion of lysosomes similarly to Rab7 dominant-negative mutants. More importantly, expression of RILP reverses/prevents the effects of Rab7 dominant-negative mutants. All these data are consistent with a model in which RILP represents a downstream effector for Rab7 and both proteins act together in the regulation of late endocytic traffic. |
| Links |
PubMed PMC145419 Online version:10.1093/emboj/20.4.683 |
| Keywords |
Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Base Sequence; Carrier Proteins/chemistry; Carrier Proteins/genetics; Carrier Proteins/metabolism; DNA, Complementary; Endocytosis; HeLa Cells; Humans; Lysosomes/metabolism; Molecular Sequence Data; Mutation; Protein Transport; Two-Hybrid System Techniques; rab GTP-Binding Proteins/metabolism |
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