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PMID:19399181
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| Citation |
Romanowska, M, Evans, A, Kellock, D, Bray, SE, McLean, K, Donandt, S and Foerster, J (2009) Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon. PLoS ONE 4:e5354 |
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| Abstract |
Wnt5a is a member of the wingless-type patterning regulators important in pre-natal development. The expression and distribution of Wnt5a and its receptors frizzled (fzd) 3 and fzd 5 in adult human skin have not been comprehensively studied to date. |
| Links |
PubMed PMC2670517 Online version:10.1371/journal.pone.0005354 |
| Keywords |
Adult; Amyloid beta-Protein Precursor/biosynthesis; Cells, Cultured; Frizzled Receptors/genetics; Frizzled Receptors/metabolism; Gene Expression; Humans; Interferon Type I/genetics; Interferon Type I/metabolism; Interferon Type I/pharmacology; Keratinocytes/drug effects; Keratinocytes/metabolism; Protease Nexins; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Psoriasis/genetics; Psoriasis/metabolism; Psoriasis/pathology; Receptors, Cell Surface/biosynthesis; Recombinant Proteins; Skin/anatomy & histology; Skin/drug effects; Skin/metabolism; Tissue Distribution; Transfection; Ubiquitins/biosynthesis; Up-Regulation; Wnt Proteins/genetics; Wnt Proteins/metabolism |
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