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PMID:20133945
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| Citation |
Bolz, DD, Tenor, JL and Aballay, A (2010) A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection. J. Biol. Chem. 285:10832-40 |
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| Abstract |
Yersinia pestis has acquired a variety of complex strategies that enable the bacterium to overcome defenses in different hosts and ensure its survival and successful transmission. A full-genome microarray analysis on Caenorhabditis elegans infected with Y. pestis shows enrichment in genes that are markers of innate immune responses and regulated by a conserved PMK-1/p38 MAPK. Consistent with a role in regulating expression of immune effectors, inhibition of PMK-1/p38 by mutation or RNA interference enhances susceptibility to Y. pestis. Further studies of mosaic animals where PMK-1/p38 is exclusively inhibited or overexpressed in a tissue-specific manner indicate that PMK-1/p38 controls expression of a CUB-like family of immune genes at the cell-autonomous level. Given the conserved nature of PMK-1/p38 MAPK-mediated signaling and innate immune responses, PMK-1/p38 MAPK may play a role in the immune response against Y. pestis in natural hosts. |
| Links |
PubMed PMC2856289 Online version:10.1074/jbc.M109.091629 |
| Keywords |
Animals; Animals, Genetically Modified; Biological Markers/metabolism; Blotting, Western; Caenorhabditis elegans/growth & development; Caenorhabditis elegans/immunology; Caenorhabditis elegans/microbiology; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Flow Cytometry; Gene Expression Profiling; Mitogen-Activated Protein Kinases/genetics; Mitogen-Activated Protein Kinases/metabolism; Oligonucleotide Array Sequence Analysis; Plague/immunology; Plague/microbiology; RNA, Messenger/genetics; RNA, Messenger/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Yersinia pestis/pathogenicity; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism |
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