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PMID:18451108
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| Citation |
Merz, K, Hondele, M, Goetze, H, Gmelch, K, Stoeckl, U and Griesenbeck, J (2008) Actively transcribed rRNA genes in S. cerevisiae are organized in a specialized chromatin associated with the high-mobility group protein Hmo1 and are largely devoid of histone molecules. Genes Dev. 22:1190-204 |
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| Abstract |
Synthesis of ribosomal RNAs (rRNAs) is the major transcriptional event in proliferating cells. In eukaryotes, ribosomal DNA (rDNA) is transcribed by RNA polymerase I from a multicopy locus coexisting in at least two different chromatin states. This heterogeneity of rDNA chromatin has been an obstacle to defining its molecular composition. We developed an approach to analyze differential protein association with each of the two rDNA chromatin states in vivo in the yeast Saccharomyces cerevisiae. We demonstrate that actively transcribed rRNA genes are largely devoid of histone molecules, but instead associate with the high-mobility group protein Hmo1. |
| Links |
PubMed PMC2335315 Online version:10.1101/gad.466908 |
| Keywords |
Blotting, Southern; Chromatin/chemistry; Chromatin/genetics; Chromatin/metabolism; Cross-Linking Reagents/chemistry; DNA, Fungal/genetics; DNA, Fungal/metabolism; DNA, Ribosomal/genetics; DNA, Ribosomal/metabolism; Ficusin/chemistry; Gene Dosage; Genes, rRNA/genetics; High Mobility Group Proteins/genetics; High Mobility Group Proteins/metabolism; Histones/metabolism; Models, Genetic; Promoter Regions, Genetic/genetics; Protein Binding; Ribosomal Proteins/metabolism; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; Transcription, Genetic |
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