GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
TableEdit
PMID:19293385
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
See Help for Help on this wiki. See the documentation for how to use the table editor
Citation |
Lee, JR, Lee, SS, Jang, HH, Lee, YM, Park, JH, Park, SC, Moon, JC, Park, SK, Kim, SY, Lee, SY, Chae, HB, Jung, YJ, Kim, WY, Shin, MR, Cheong, GW, Kim, MG, Kang, KR, Lee, KO, Yun, DJ and Lee, SY (2009) Heat-shock dependent oligomeric status alters the function of a plant-specific thioredoxin-like protein, AtTDX. Proc. Natl. Acad. Sci. U.S.A. 106:5978-83 |
---|---|
Abstract |
We found that Arabidopsis AtTDX, a heat-stable and plant-specific thioredoxin (Trx)-like protein, exhibits multiple functions, acting as a disulfide reductase, foldase chaperone, and holdase chaperone. The activity of AtTDX, which contains 3 tetratricopeptide repeat (TPR) domains and a Trx motif, depends on its oligomeric status. The disulfide reductase and foldase chaperone functions predominate when AtTDX occurs in the low molecular weight (LMW) form, whereas the holdase chaperone function predominates in the high molecular weight (HMW) complexes. Because deletion of the TPR domains results in a significant enhancement of AtTDX disulfide reductase activity and complete loss of the holdase chaperone function, our data suggest that the TPR domains of AtTDX block the active site of Trx and play a critical role in promoting the holdase chaperone function. The oligomerization status of AtTDX is reversibly regulated by heat shock, which causes a transition from LMW to HMW complexes with concomitant functional switching from a disulfide reductase and foldase chaperone to a holdase chaperone. Overexpression of AtTDX in Arabidopsis conferred enhanced heat shock resistance to plants, primarily via its holdase chaperone activity. |
Links |
PubMed PMC2667072 Online version:10.1073/pnas.0811231106 |
Keywords |
Arabidopsis Proteins/physiology; Dimerization; Heat-Shock Response/genetics; Molecular Chaperones; Molecular Weight; NADH, NADPH Oxidoreductases; Thioredoxins/physiology |
public |
Cancel |