GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
TableEdit
PMID:19151721
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
See Help for Help on this wiki. See the documentation for how to use the table editor
Citation |
Cruz-Munoz, ME, Dong, Z, Shi, X, Zhang, S and Veillette, A (2009) Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat. Immunol. 10:297-305 |
---|---|
Abstract |
CRACC is a self-associating member of the signaling lymphocytic activation molecule family that is expressed on cells of the immune system, including natural killer cells and activated T cells. Here we examine the function and mechanism of action of CRACC using several complementary approaches, including the generation of a CRACC-deficient mouse. Our results demonstrate that CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. CRACC was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins. |
Links |
PubMed Online version:10.1038/ni.1693 |
Keywords |
Adaptor Proteins, Signal Transducing; Animals; Gene Expression Profiling; Killer Cells, Natural/immunology; Killer Cells, Natural/metabolism; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Receptors, Immunologic/immunology; Receptors, Immunologic/metabolism; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; Transcription Factors/immunology; Transcription Factors/metabolism |
public |
Cancel |