GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

TableEdit

Jump to: navigation, search

PMID:19151721

You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor

Citation

Cruz-Munoz, ME, Dong, Z, Shi, X, Zhang, S and Veillette, A (2009) Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat. Immunol. 10:297-305

Abstract

CRACC is a self-associating member of the signaling lymphocytic activation molecule family that is expressed on cells of the immune system, including natural killer cells and activated T cells. Here we examine the function and mechanism of action of CRACC using several complementary approaches, including the generation of a CRACC-deficient mouse. Our results demonstrate that CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. CRACC was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

Links

PubMed Online version:10.1038/ni.1693

Keywords

Adaptor Proteins, Signal Transducing; Animals; Gene Expression Profiling; Killer Cells, Natural/immunology; Killer Cells, Natural/metabolism; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Receptors, Immunologic/immunology; Receptors, Immunologic/metabolism; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; Transcription Factors/immunology; Transcription Factors/metabolism

public



Cancel