GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
TableEdit
PMID:10607756
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
See Help for Help on this wiki. See the documentation for how to use the table editor
| Citation |
Takeuchi, O, Takeda, K, Hoshino, K, Adachi, O, Ogawa, T and Akira, S (2000) Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int. Immunol. 12:113-7 |
|---|---|
| Abstract |
MyD88 is an adaptor molecule essential for signaling via the Toll-like receptor (TLR)/IL-1 receptor family. TLR4 is a member of the TLR family and a point mutation in the Tlr4 gene causes hyporesponsiveness to lipopolysaccharide (LPS) in C3H/HeJ mice. We have previously shown that both TLR4- and MyD88-deficient mice are hyporesponsive to LPS. In this study we examined the responsiveness of these two knockout mice to various bacterial cell wall components. Cells from TLR4-deficient mice responded to several kinds of LPS, peptidoglycan and crude cell wall preparation from Gram-positive bacteria and mycobacterial lysates. In contrast, macrophages and splenocytes from MyD88-deficient mice did not respond to any of the bacterial components we tested. These results show that MyD88 is essential for the cellular response to bacterial cell wall components. |
| Links | |
| Keywords |
Adaptor Proteins, Signal Transducing; Animals; Antigens, Differentiation/genetics; Antigens, Differentiation/metabolism; Cell Wall/immunology; Drosophila Proteins; Gram-Negative Bacteria/immunology; Gram-Positive Bacteria/immunology; Lipopolysaccharides/immunology; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Mice; Mice, Inbred C3H; Mice, Knockout; Mycobacterium/immunology; Myeloid Differentiation Factor 88; Peptidoglycan/immunology; Receptors, Cell Surface/genetics; Receptors, Cell Surface/metabolism; Receptors, Immunologic; Signal Transduction; Toll-Like Receptor 4; Toll-Like Receptors |
| public |
| Cancel |
