GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

TableEdit

Jump to: navigation, search

PMID:19393221

You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor

Citation

Jiang, Q, Liu, D, Gong, Y, Wang, Y, Sun, S, Gui, Y and Song, H (2009) yap is required for the development of brain, eyes, and neural crest in zebrafish. Biochem. Biophys. Res. Commun. 384:114-9

Abstract

The Yes-associated protein (YAP) is a small protein that binds to many transcription factors and modulates their activity. Bioinformatics analysis indicated that zebrafish Yap shares high identity with its orthologs in fruit fly, chicken, mouse, and human. Expression analysis revealed that maternal transcripts of yap are ubiquitous, and endogenous yap is chronologically expressed in the notochord, brain, eyes, branchial arches, and pectoral fins. Knockdown of yap causes distinct morphological defects in embryos, which display a small head with smaller eyes than normal and fewer cartilages in the branchial arches. Proneural and neuronal gene expression in yap morphant brain is significantly reduced. The expression of crestin is also markedly reduced in all recognizable arch-associated regions of yap morphants. Furthermore, TUNEL analysis revealed that there is a marked increase in cell death in yap morphant brain. In conclusion, zebrafish yap is required for the development of the brain, eyes, and neural crest during embryogenesis.

Links

PubMed Online version:10.1016/j.bbrc.2009.04.070

Keywords

Animals; Brain/embryology; Carrier Proteins/genetics; Carrier Proteins/physiology; Eye/embryology; Humans; Mice; Neural Crest/embryology; Zebrafish/embryology; Zebrafish/genetics; Zebrafish/metabolism; Zebrafish Proteins/genetics; Zebrafish Proteins/physiology

public



Cancel