GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
TableEdit
PMID:12163178
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
See Help for Help on this wiki. See the documentation for how to use the table editor
| Citation |
Li, QH, Haga, I, Shimizu, T, Itoh, M, Kurosaki, T and Fujisawa, J (2002) Retardation of the G2-M phase progression on gene disruption of RNA binding protein Sam68 in the DT40 cell line. FEBS Lett. 525:145-50 |
|---|---|
| Abstract |
Sam68 is an RNA binding protein that is tyrosine-phosphorylated by Src during mitosis and has been postulated to have a role in cell cycle control by modulating RNA metabolism. To elucidate the function of this protein, we isolated a Sam68-deficient DT40 cell line by gene disruption. The Sam68-deficient cells exhibited markedly decreased growth and the growth retardation was due to elongation of the G2-M phase, however, the kinase activity associated with Cdc2 remained unaltered. Our results indicate that Sam68 may play a critical role in G2-M progression in a manner independent of the control of Cyclin/Cdc2 kinase activity. |
| Links | |
| Keywords |
Animals; B-Lymphocytes/cytology; B-Lymphocytes/metabolism; CDC2 Protein Kinase/metabolism; Cell Division/genetics; Cell Division/physiology; Cell Line; Chickens; Clone Cells/cytology; Clone Cells/metabolism; Enzyme Activation/physiology; G2 Phase/physiology; Gene Targeting; Mitosis/physiology; Molecular Sequence Data; RNA-Binding Proteins/genetics |
| public |
| Cancel |
