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PMID:18833190

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Citation

Houwing, S, Berezikov, E and Ketting, RF (2008) Zili is required for germ cell differentiation and meiosis in zebrafish. EMBO J. 27:2702-11

Abstract

Small RNAs exert an effect through diverse RNA interference pathways to transcriptionally or post-transcriptionally silence their targets. The Piwi-interacting RNAs (piRNAs) represent a germline-specific small RNA pathway where Piwi proteins themselves are thought to mediate piRNA biosynthesis. Here, we provide strong evidence for a piRNA amplification loop in zebrafish, in which Ziwi and Zili bind piRNAs of opposite polarity. Furthermore, we describe a function for Zili in transposon defense and germ cell differentiation, as well as a crucial function in meiosis, significantly extending the function of Piwi proteins beyond the control of transposable elements in vertebrates.

Links

PubMed PMC2572183 Online version:10.1038/emboj.2008.204

Keywords

Alleles; Animals; Cell Differentiation; Cell Nucleus/metabolism; Cloning, Molecular; Cytoplasm/metabolism; DNA Transposable Elements; Germ Cells/cytology; Meiosis; Models, Biological; Models, Genetic; RNA, Small Interfering/metabolism; RNA-Binding Proteins/genetics; RNA-Binding Proteins/physiology; Zebrafish; Zebrafish Proteins/genetics; Zebrafish Proteins/physiology

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