GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
TableEdit
PMID:9271578
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
See Help for Help on this wiki. See the documentation for how to use the table editor
| Citation |
Sinclair, DA, Mills, K and Guarente, L (1997) Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277:1313-6 |
|---|---|
| Abstract |
The SGS1 gene of yeast encodes a DNA helicase with homology to the human WRN gene. Mutations in WRN result in Werner's syndrome, a disease with symptoms resembling premature aging. Mutation of SGS1 is shown to cause premature aging in yeast mother cells on the basis of a shortened life-span and the aging-induced phenotypes of sterility and redistribution of the Sir3 silencing protein from telomeres to the nucleolus. Further, in old sgs1 cells the nucleolus is enlarged and fragmented-changes that also occur in old wild-type cells. These findings suggest a conserved mechanism of cellular aging that may be related to nucleolar structure. |
| Links | |
| Keywords |
Cell Aging; Cell Division; Cell Nucleolus/chemistry; Cell Nucleolus/metabolism; Cell Nucleolus/ultrastructure; DNA Helicases/genetics; DNA Helicases/physiology; Exodeoxyribonucleases; Fluorescent Antibody Technique, Indirect; Fungal Proteins/analysis; Genes, Fungal; Humans; Mutation; Phenotype; RecQ Helicases; Saccharomyces cerevisiae/cytology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/physiology; Saccharomyces cerevisiae/ultrastructure; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Trans-Activators/analysis; Werner Syndrome/genetics |
| public |
| Cancel |
