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PMID:16275384
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| Citation |
Lin, W, Truong, N, Grossman, WJ, Haribhai, D, Williams, CB, Wang, J, Martín, MG and Chatila, TA (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J. Allergy Clin. Immunol. 116:1106-15 |
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| Abstract |
Regulatory T cells have been proposed to play an important role in regulating allergic inflammation. The transcription factor Foxp3 is a master switch gene that controls the development and function of natural and adaptive CD4(+)CD25(+) regulatory T (T(R)) cells. In human subjects loss-of-function Foxp3 mutations trigger lymphoproliferation, autoimmunity, and intense allergic inflammation in a disease termed immune dysregulation polyendocrinopathy enteropathy-X-linked syndrome. |
| Links |
PubMed Online version:10.1016/j.jaci.2005.08.046 |
| Keywords |
Animals; Cytokines/blood; Cytokines/metabolism; Disease Models, Animal; Eosinophilia/pathology; Forkhead Transcription Factors/genetics; Hypergammaglobulinemia/blood; Hypergammaglobulinemia/genetics; Hypersensitivity/genetics; Hypersensitivity/pathology; Hypersensitivity/physiopathology; Immunoglobulin E/blood; Inflammation/genetics; Inflammation/pathology; Mice; Mice, Knockout; Respiratory System/pathology; STAT6 Transcription Factor/deficiency; STAT6 Transcription Factor/metabolism; Th1 Cells/metabolism; Th2 Cells/metabolism |
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