GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
TableEdit
PMID:11971948
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
See Help for Help on this wiki. See the documentation for how to use the table editor
| Citation |
King, VL, Szilvassy, SJ and Daugherty, A (2002) Interleukin-4 deficiency promotes gallstone formation. J. Lipid Res. 43:768-71 |
|---|---|
| Abstract |
Feeding interleukin-4 (IL-4) deficient C57BL/6 LDL receptor (LDLr)(-/-) mice a modified diet to investigate the role of this cytokine in cholesterol metabolism led to an unexpected phenotype. IL-4(-/-) --> LDLr(-/-) mice had enlarged gallbladders and an increased mortality that was preceded by acute body weight loss. To determine if IL-4 deficiency accounted for these findings, C57BL/6 IL-4(+/+) and IL-4(-/-) mice were fed either a normal or modified diet. IL-4 deficiency did not alter bile composition or cause liver toxicity in mice fed a fat-enriched diet. Following 8 weeks of feeding a fat-enriched diet, no gallstones were detected in IL-4(+/+) mice, and only 20% had cholesterol crystals. In contrast, IL-4(-/-) mice had a 100% incidence of gallstones and cholesterol crystals. IL-4(-/-) deficiency also increased serum concentrations of bilirubin following feeding a fat-enriched diet. Therefore, these studies revealed an unexpected finding that IL-4 deficiency predisposes to gallstone formation. |
| Links | |
| Keywords |
Alanine Transaminase/blood; Animals; Aspartate Aminotransferases/blood; Bile/chemistry; Bilirubin/metabolism; Blood Proteins/metabolism; Cholelithiasis/genetics; Cholesterol/metabolism; Interleukin-4/deficiency; Interleukin-4/genetics; Interleukin-4/physiology; Lipid Metabolism; Lipids/blood; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, LDL/deficiency; Receptors, LDL/genetics; Receptors, LDL/physiology; Triglycerides/metabolism |
| public |
| Cancel |
