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PMID:11063934
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| Citation |
Walworth, NC (2000) Cell-cycle checkpoint kinases: checking in on the cell cycle. Curr. Opin. Cell Biol. 12:697-704 |
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| Abstract |
In response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA repair. The idea that checkpoint controls are an integral component of normal cell-cycle progression has arisen as a result of studies in Drosophila and mice. In addition, an appreciation that DNA damage arises as a natural consequence of cellular metabolism, including DNA replication itself, has influenced thinking regarding the nature of checkpoint pathways. |
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| Keywords |
Animals; Cell Cycle/physiology; Cell Cycle Proteins; Cell Transformation, Neoplastic/genetics; DNA Repair/physiology; DNA Replication/physiology; DNA-Binding Proteins; Drosophila; Embryo, Mammalian/enzymology; Embryo, Mammalian/pathology; Embryo, Nonmammalian/enzymology; Embryo, Nonmammalian/pathology; Genes, cdc/physiology; Genetic Predisposition to Disease; Mice; Protein Kinases/genetics; Protein Kinases/metabolism; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/metabolism; Tumor Suppressor Protein p53/metabolism; Tumor Suppressor Proteins |
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