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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

protected

involved_in

GO:0042976

activation of Janus kinase activity

PMID:18086859

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007250

activation of NF-kappaB-inducing kinase activity

PMID:18086859

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0032991

protein-containing complex

PMID:18086859

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:16301747

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000185

activation of MAPKKK activity

PMID:16301747

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0089720

caspase binding

PMID:16301747

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:A0A1D5P1T2

F

occurs_in:(CL:0000236)

Seeded From UniProt

complete

protected

enables

GO:0031435

mitogen-activated protein kinase kinase kinase binding

PMID:16301747

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(CL:0000236)

Seeded From UniProt

complete

protected

involved_in

GO:0050853

B cell receptor signaling pathway

PMID:16301747

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000236)

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:18086859

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0070970

interleukin-2 secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0050870

positive regulation of T cell activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0050776

regulation of immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0048872

homeostasis of number of cells

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0046649

lymphocyte activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0045580

regulation of T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0045577

regulation of B cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0045086

positive regulation of interleukin-2 biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0045061

thymic T cell selection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0042110

T cell activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0042102

positive regulation of T cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0042100

B cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0030890

positive regulation of B cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0030183

B cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

involved_in

GO:0007165

signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

C

Seeded From UniProt

complete

protected

involved_in

GO:0002377

immunoglobulin production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

P

Seeded From UniProt

complete

protected

part_of

GO:0001772

immunological synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CIS0
ensembl:ENSMUSP00000082941

C

Seeded From UniProt

complete

protected

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BXL7
ensembl:ENSP00000380150

P

Seeded From UniProt

complete

protected

enables

GO:0050700

CARD domain binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BXL7
ensembl:ENSP00000380150

F

Seeded From UniProt

complete

protected

part_of

GO:0045121

membrane raft

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BXL7
ensembl:ENSP00000380150

C

Seeded From UniProt

complete

protected

involved_in

GO:0038202

TORC1 signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BXL7
ensembl:ENSP00000380150

P

Seeded From UniProt

complete

protected

part_of

GO:0032449

CBM complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BXL7
ensembl:ENSP00000380150

C

Seeded From UniProt

complete

protected

involved_in

GO:0031295

T cell costimulation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BXL7
ensembl:ENSP00000380150

P

Seeded From UniProt

complete

protected

involved_in

GO:0007249

I-kappaB kinase/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BXL7
ensembl:ENSP00000380150

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BXL7
ensembl:ENSP00000380150

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BXL7
ensembl:ENSP00000380150

C

Seeded From UniProt

complete

protected

involved_in

GO:0001819

positive regulation of cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BXL7
ensembl:ENSP00000380150

P

Seeded From UniProt

complete

protected

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001315

P

Seeded From UniProt

complete

protected

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033538

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

Reactome:R-GGA-1169563

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete



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